4rmj: Difference between revisions
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New page: '''Unreleased structure''' The entry 4rmj is ON HOLD Authors: Rumpf, T., Schiedel, M., Karaman, B., Roessler, C., North, B.J., Lehotzky, A., Olah, J., Ladwein, K.I., Schmidtkunz, K., Ga... |
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==Human Sirt2 in complex with ADP ribose and nicotinamide== | |||
<StructureSection load='4rmj' size='340' side='right'caption='[[4rmj]], [[Resolution|resolution]] 1.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4rmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RMJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmj OCA], [https://pdbe.org/4rmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rmj RCSB], [https://www.ebi.ac.uk/pdbsum/4rmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> | |||
==See Also== | |||
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Einsle O]] | |||
[[Category: Gajer M]] | |||
[[Category: Gerhardt S]] | |||
[[Category: Jung M]] | |||
[[Category: Karaman B]] | |||
[[Category: Ladwein KI]] | |||
[[Category: Lehotzky A]] | |||
[[Category: North BJ]] | |||
[[Category: Olah J]] | |||
[[Category: Ovadi J]] | |||
[[Category: Pannek M]] | |||
[[Category: Roessler C]] | |||
[[Category: Rumpf T]] | |||
[[Category: Schiedel M]] | |||
[[Category: Schmidtkunz K]] | |||
[[Category: Schutkowski M]] | |||
[[Category: Sinclair DA]] | |||
[[Category: Sippl W]] | |||
[[Category: Steegborn C]] | |||
Latest revision as of 12:53, 1 March 2024
Human Sirt2 in complex with ADP ribose and nicotinamide
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