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==Crystal structure of human ALDH3A1 with its isozyme selective inhibitor - N-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide==
==Crystal structure of human ALDH3A1 with its isozyme selective inhibitor - N-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide==
<StructureSection load='4h80' size='340' side='right' caption='[[4h80]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4h80' size='340' side='right'caption='[[4h80]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h80]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H80 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h80]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H80 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=04T:N-(4-{[4-(METHYLSULFONYL)-2-NITROPHENYL]AMINO}PHENYL)ACETAMIDE'>04T</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sza|3sza]], [[3szb|3szb]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=04T:N-(4-{[4-(METHYLSULFONYL)-2-NITROPHENYL]AMINO}PHENYL)ACETAMIDE'>04T</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(P)(+)) Aldehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.5 1.2.1.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h80 OCA], [https://pdbe.org/4h80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h80 RCSB], [https://www.ebi.ac.uk/pdbsum/4h80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h80 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h80 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h80 RCSB], [http://www.ebi.ac.uk/pdbsum/4h80 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AL3A1_HUMAN AL3A1_HUMAN] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.


==See Also==
==See Also==
*[[Aldehyde dehydrogenase|Aldehyde dehydrogenase]]
*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hurley, T D.]]
[[Category: Homo sapiens]]
[[Category: Parajuli, B.]]
[[Category: Large Structures]]
[[Category: Catalyzes benzaldehyde]]
[[Category: Hurley TD]]
[[Category: Dehydrogenase]]
[[Category: Parajuli B]]
[[Category: Nadp+ binding]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Rossmann fold]]
Retrieved from "https://proteopedia.org/4h80"