4u6v: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody== | ==Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody== | ||
<StructureSection load='4u6v' size='340' side='right' caption='[[4u6v]], [[Resolution|resolution]] 2.56Å' scene=''> | <StructureSection load='4u6v' size='340' side='right'caption='[[4u6v]], [[Resolution|resolution]] 2.56Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4u6v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6V OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4u6v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_TCH60 Staphylococcus aureus subsp. aureus TCH60]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U6V FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6v OCA], [https://pdbe.org/4u6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u6v RCSB], [https://www.ebi.ac.uk/pdbsum/4u6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u6v ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HLA_STAA8 HLA_STAA8] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4u6v" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Hemolysin 3D structures|Hemolysin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Staphylococcus aureus subsp. aureus TCH60]] | ||
[[Category: | [[Category: Cheng L]] | ||
[[Category: Dall'Acqua WF]] | |||
[[Category: | [[Category: Damschroder MM]] | ||
[[Category: | [[Category: Oganesyan VY]] | ||
[[Category: | [[Category: Peng L]] | ||
[[Category: | [[Category: Sadowska A]] | ||
[[Category: | [[Category: Sellman B]] | ||
[[Category: | [[Category: Tkaczyk C]] | ||
[[Category: | [[Category: Wu H]] | ||
[[Category: | |||
Latest revision as of 07:25, 27 September 2023
Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody
| ||||||||||||
