4rou: Difference between revisions

Latest revision as of 08:59, 20 March 2024

Auto-inhibition Mechanism of Human Mitochondrial RNase P Protein Complex

Structural highlights

4rou is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.713Å
Ligands:	CL, ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MRPP3_HUMAN The disease is caused by variants affecting the gene represented in this entry.

Function

MRPP3_HUMAN Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).^[1] ^[2] ^[3]

References

↑ Holzmann J, Frank P, Loffler E, Bennett KL, Gerner C, Rossmanith W. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell. 2008 Oct 31;135(3):462-74. PMID:18984158 doi:S0092-8674(08)01135-5
↑ Reinhard L, Sridhara S, Hallberg BM. Structure of the nuclease subunit of human mitochondrial RNase P. Nucleic Acids Res. 2015 May 7. pii: gkv481. PMID:25953853 doi:https://dx.doi.org/10.1093/nar/gkv481
↑ Hochberg I, Demain LAM, Richer J, Thompson K, Urquhart JE, Rea A, Pagarkar W, Rodríguez-Palmero A, Schlüter A, Verdura E, Pujol A, Quijada-Fraile P, Amberger A, Deutschmann AJ, Demetz S, Gillespie M, Belyantseva IA, McMillan HJ, Barzik M, Beaman GM, Motha R, Ng KY, O'Sullivan J, Williams SG, Bhaskar SS, Lawrence IR, Jenkinson EM, Zambonin JL, Blumenfeld Z, Yalonetsky S, Oerum S, Rossmanith W, Yue WW, Zschocke J, Munro KJ, Battersby BJ, Friedman TB, Taylor RW, O'Keefe RT, Newman WG. Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations. Am J Hum Genet. 2021 Nov 4;108(11):2195-2204. PMID:34715011 doi:10.1016/j.ajhg.2021.10.002

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Holzmann J, Frank P, Loffler E, Bennett KL, Gerner C, Rossmanith W. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell. 2008 Oct 31;135(3):462-74. PMID:18984158 doi:S0092-8674(08)01135-5

[2] Reinhard L, Sridhara S, Hallberg BM. Structure of the nuclease subunit of human mitochondrial RNase P. Nucleic Acids Res. 2015 May 7. pii: gkv481. PMID:25953853 doi:https://dx.doi.org/10.1093/nar/gkv481

[3] Hochberg I, Demain LAM, Richer J, Thompson K, Urquhart JE, Rea A, Pagarkar W, Rodríguez-Palmero A, Schlüter A, Verdura E, Pujol A, Quijada-Fraile P, Amberger A, Deutschmann AJ, Demetz S, Gillespie M, Belyantseva IA, McMillan HJ, Barzik M, Beaman GM, Motha R, Ng KY, O'Sullivan J, Williams SG, Bhaskar SS, Lawrence IR, Jenkinson EM, Zambonin JL, Blumenfeld Z, Yalonetsky S, Oerum S, Rossmanith W, Yue WW, Zschocke J, Munro KJ, Battersby BJ, Friedman TB, Taylor RW, O'Keefe RT, Newman WG. Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations. Am J Hum Genet. 2021 Nov 4;108(11):2195-2204. PMID:34715011 doi:10.1016/j.ajhg.2021.10.002

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4rou is ON HOLD
+==Auto-inhibition Mechanism of Human Mitochondrial RNase P Protein Complex==
+<StructureSection load='4rou' size='340' side='right'caption='[[4rou]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
-Authors: Fengzhi Li, Xiaofen Liu, Xue Yang, Yuequan Shen
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ROU FirstGlance]. <br>
-Description: Auto-inhibition Mechanism of Human Mitochondrial RNase P Protein Complex
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.713&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rou OCA], [https://pdbe.org/4rou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rou RCSB], [https://www.ebi.ac.uk/pdbsum/4rou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rou ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/MRPP3_HUMAN MRPP3_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/MRPP3_HUMAN MRPP3_HUMAN] Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).<ref>PMID:18984158</ref> <ref>PMID:25953853</ref> <ref>PMID:34715011</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li F]]
+[[Category: Liu X]]
+[[Category: Shen Y]]
+[[Category: Yang X]]

4rou: Difference between revisions

Latest revision as of 08:59, 20 March 2024

Auto-inhibition Mechanism of Human Mitochondrial RNase P Protein Complex

Structural highlights

Disease

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools