Aerolysin: Difference between revisions

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[[Image:1pre.png|left|200px|thumb|Crystal Structure of Proaerolysin [[1pre]]]]
<StructureSection load='1pre' size='340' side='right' caption='Proaerolysin dimer (PDB code [[1pre]]).' scene='43/430021/Cv/2'>
{{STRUCTURE_1pre|  PDB=1pre | SIZE=400| SCENE=Aerolysin/Cv/1 |right|CAPTION=Proaerolysin dimer [[1pre]] }}


[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''.  It uses GPI-anchored proteins on the cell surface as receptors.  Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death.  It is secreted as an inactive precursor '''proaerolysin''' (proAer) which gets cleaved at Arg-432 by furin to produce the active Aer.<ref>PMID:7510043</ref>  For toxins in Proteopedia see [[Toxins]].


[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''.  It uses GPI-anchored proteins on the cell surface as receptors.  Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death.  It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, ''i.e.'' the crystal structure of Proaerolysin ([[1pre]]).  For toxins in Proteopedia see [[Toxins]].


__NOTOC__
__NOTOC__
== 3D Structures of Aerolysin ==
== 3D Structures of Aerolysin ==
[[Aerolysin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* Aerolysin
**[[3g4n]], [[3g4o]] – Aer (mutant)
 
* Proaerolysin


**[[1pre]] - proAer<br />
== References ==
**[[3c0m]], [[3c0n]], [[1z52]] - proAer (mutant)<br />
<references/>
**[[3c0o]] - proAer (mutant)+mannose-6-phosphate
}}
[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/Aerolysin"