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==The crystal structure of discoidin domain from muskelin==
==The crystal structure of discoidin domain from muskelin==
<StructureSection load='4pqq' size='340' side='right' caption='[[4pqq]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='4pqq' size='340' side='right'caption='[[4pqq]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4pqq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4pqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqq RCSB], [http://www.ebi.ac.uk/pdbsum/4pqq PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqq OCA], [https://pdbe.org/4pqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pqq RCSB], [https://www.ebi.ac.uk/pdbsum/4pqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqq ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/MKLN1_MOUSE MKLN1_MOUSE] Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
Muskelin is an intracellular kelch-repeat protein comprised of discoidin, LisH, CTLH and kelch-repeat domains. It is involved in cell adhesion and the regulation of cytoskeleton dynamics as well as being a component of a putative E3 ligase complex. Here, the first crystal structure of mouse muskelin discoidin domain (MK-DD) is reported at 1.55 A resolution, which reveals a distorted eight-stranded beta-barrel with two short alpha-helices at one end of the barrel. Interestingly, the N- and C-termini are not linked by the disulfide bonds found in other eukaryotic discoidin structures. A highly conserved MIND motif appears to be the determinant for MK-DD specific interaction together with the spike loops. Analysis of interdomain interaction shows that MK-DD binds the kelch-repeat domain directly and that this interaction depends on the presence of the LisH domain.
 
Structure of mouse muskelin discoidin domain and biochemical characterization of its self-association.,Kim KH, Hong SK, Hwang KY, Kim EE Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2863-74. doi:, 10.1107/S139900471401894X. Epub 2014 Oct 16. PMID:25372678<ref>PMID:25372678</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hong, S K]]
[[Category: Large Structures]]
[[Category: Kim, E E]]
[[Category: Mus musculus]]
[[Category: Kim, K H]]
[[Category: Hong SK]]
[[Category: Alpha isoform]]
[[Category: Kim EE]]
[[Category: Cell spreading mediator]]
[[Category: Kim K-H]]
[[Category: Jelly-roll]]
[[Category: Phosphorylation]]
[[Category: Prostaglandin ep3 receptor]]
[[Category: Protein binding]]
[[Category: Ranbp9]]
Retrieved from "https://proteopedia.org/4pqq"