4rnq: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4rnq is ~~ON HOLD until Paper Publication~~

==Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline==

~~Authors~~: ~~Koo~~, H.J., ~~Crenshaw, C~~.M., ~~Starks C~~., ~~Spielmann~~, H.P.~~, Chappell, J~~., ~~Noel, J~~.P.

== Structural highlights ==

<table><tr><td colspan='2'>[[4rnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNQ OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4RNQ FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~tobacco~~ 5-epi-aristolochene ~~synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=A4S:(2E,6E)-3,7-DIMETHYL-8-(PHENYLAMINO)OCTA-2,6-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>A4S</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnq OCA], [https://pdbe.org/4rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rnq RCSB], [https://www.ebi.ac.uk/pdbsum/4rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rnq ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Nicotiana tabacum]]

[[Category: Chappell J]]

[[Category: Crenshaw CM]]

[[Category: Koo HJ]]

[[Category: Noel JP]]

[[Category: Spielmann HP]]

[[Category: Starks C]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4rnq is ON HOLD  until Paper Publication
+==Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline==
+<StructureSection load='4rnq' size='340' side='right'caption='[[4rnq]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
-Authors: Koo, H.J., Crenshaw, C.M., Starks C., Spielmann, H.P., Chappell, J., Noel, J.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RNQ FirstGlance]. <br>
-Description: Crystal structure of tobacco 5-epi-aristolochene synthase (TEAS) with anilinogeranyl diphosphate (AGPP) and geraniline
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=A4S:(2E,6E)-3,7-DIMETHYL-8-(PHENYLAMINO)OCTA-2,6-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>A4S</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnq OCA], [https://pdbe.org/4rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rnq RCSB], [https://www.ebi.ac.uk/pdbsum/4rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rnq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Nicotiana tabacum]]
+[[Category: Chappell J]]
+[[Category: Crenshaw CM]]
+[[Category: Koo HJ]]
+[[Category: Noel JP]]
+[[Category: Spielmann HP]]
+[[Category: Starks C]]