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| [[Image:1lbd.gif|left|200px]] | | #REDIRECT [[6hn6]] This PDB entry is obsolete and replaced by 6hn6 |
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| {{Structure
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| |PDB= 1lbd |SIZE=350|CAPTION= <scene name='initialview01'>1lbd</scene>, resolution 2.7Å
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| |SITE=
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| |LIGAND=
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| |ACTIVITY=
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| |GENE=
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| }}
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| '''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''
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| ==Overview==
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| The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
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| ==About this Structure==
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| 1LBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].
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| ==Reference==
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| Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7760929 7760929]
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| [[Category: Homo sapiens]]
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| [[Category: Single protein]]
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| [[Category: Bourguet, W.]]
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| [[Category: Moras, D.]]
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| [[Category: SPINE, Structural Proteomics in Europe.]]
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| [[Category: nuclear receptor]]
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| [[Category: spine]]
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| [[Category: structural genomic]]
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| [[Category: structural proteomics in europe]]
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| [[Category: transcription factor]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:28:54 2008''
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This PDB entry is obsolete and replaced by 6hn6
