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| <StructureSection load='1xzl' size='350' side='right' caption='Structure of cutinase complex with inhibitor hexylphosphonate ethyl ester (PDB entry [[1xzl]])' scene=''> | | <StructureSection load='4oyl' size='350' side='right' caption='Structure of cutinase (PDB entry [[4oyl]])' scene='55/551226/Cv/1'> |
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| '''Cutinase''' (CUT) catalyzes the conversion of cutin to cutin monomers. Cutin is a main component of the plant cuticle. Polymeric cutin which is composed of hydroxyl and hydroxyepoxy fatty acids is found in the outer layer of plants. CUT is found in fungi and bacteria. CUT degrades the cutin enabling pathogens’ penetration into plant cells. Inhibition of CUT can prevent fungal plant infection. CUT is inhibited by organophosphates like E600 (diethyl-p-nitrophenyl phosphate)) and organophosphonates. | | '''Cutinase''' (CUT) or '''α/β hydrolase family protein''' the conversion of cutin to cutin monomers. Cutin is a main component of the plant cuticle. Polymeric cutin which is composed of hydroxyl and hydroxyepoxy fatty acids is found in the outer layer of plants. CUT is found in fungi and bacteria. CUT degrades the cutin enabling pathogens’ penetration into plant cells. CUT is inhibited by organophosphates like E600 (diethyl-p-nitrophenyl phosphate) and organophosphonates.<ref>PMID:9175860</ref> |
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| == 3D Structures of cutinase == | | == Relevance == |
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| | Inhibition of CUT can prevent fungal plant infection<ref>PMID:17758793</ref>. |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | == Structural highlights == |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Cutinase
| | Upon CUT inhibition by organophosphates the <scene name='55/551226/Cv/3'>catalytic triad of Ser-His-Asp exhibits esterification of Ser and ethylation of His</scene>.<ref>PMID:24832484</ref> |
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| **[[1cus]], [[2cut]], [[1oxm]], [[1cex]], [[1agy]], [[3qpa]] – NhCUT – ''Nectria haematococca''<BR />
| | == 3D Structures of cutinase == |
| **[[1ffa]], [[1ffb]], [[1ffc]], [[1ffd]], [[1ffe]], [[1cua]], [[1cub]], [[1cuc]], [[1cud]], [[1cue]], [[1cuf]], [[1cug]], [[1cuh]], [[1cui]], [[1cuj]], [[1cuu]], [[1cuv]], [[1cuw]], [[1cux]], [[1cuy]], [[1cuz]], [[1xza]], [[1xzb]], [[1xzc]], [[1xzd]], [[1xze]], [[1xzf]], [[1xzg]], [[1xzh]], [[1xzi]], [[1xzj]] – NhCUT (mutant)<BR />
| | [[Cutinase 3D structures]] |
| **[[3dcn]] – GcCUT –'' Glomerella cingulata''<BR />
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| **[[3gbs]] – CUT – ''Aspergillus oryzae'' <BR />
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| **[[3esc]] – CUT – ''Fusarium solani''<br />
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| *Cutinase complex with inhibitor
| | </StructureSection> |
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| **[[1xzl]] – NhCUT + hexylphosphonate ethyl ester<BR />
| | == References == |
| **[[1xzk]] – NhCUT + di-isopropyl phosphate <BR />
| | <references/> |
| **[[1xzm]] – NhCUT + undecyl chloro phosphonate ester<BR />
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| **[[3dd5]] – GcCUT + E600 <BR />
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| **[[3dea]] – GcCUT + PETFP <BR />
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| **[[3ef3]], [[3esa]], [[3esb]], [[3eac]], [[3esd]] – NhCUT + Pt inhibitor <BR />
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| **[[3qpc]] – NhCUT + paraoxon <BR />
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| **[[3qpd]] – NhCUT + phosphoserine <BR />
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| }}
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| [[Category: Topic Page]] | | [[Category: Topic Page]] |
