Cyclohydrolase: Difference between revisions

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<StructureSection load='1wuq' size='340' side='right' caption='Structure of GTP cyclohydrolase I pentamer complex with 8-oxo-GTP (stick model) and Zn+2 ion (grey) (PDB code [[1wuq]]).' scene=''>
<StructureSection load='1n3r' size='350' side='right' caption='Structure of GTP cyclohydrolase I pentamer complex with GTP (PDB code [[1n3r]]).' scene='59/595207/Cv/4'>


== Function ==
== Function ==


• '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate.  GCH I is part of the folate and biopterin biosynthesis<br />
'''Cyclohydrolase''' is an enzyme which catalyzes the reversible cyclization or the ring opening of a purine ring.
• '''GTP cyclohydrolase II''' catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism. <br />
 
• '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide.  ICH is part of the purine biosynthesis<br />
• '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate.  GCH I is part of the folate and biopterin biosynthesis<ref>PMID:7663943</ref> <br />
• '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin.  MCH is part of the folate biosynthesis<br />
• '''GTP cyclohydrolase II''' catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism.<ref>PMID:16115872</ref>  <br />
• '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide.  ICH is part of the purine biosynthesis<ref>PMID:17407260</ref> See also [[Bifunctional purine biosynthesis protein PURH]].<br />
• '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin.  MCH is part of the folate biosynthesis<ref>PMID:23013430</ref> <br />
*'''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells.<ref>PMID:10828945</ref>
*'''Phosphoribosyl AMP-cyclohydrolase''' catalyzes the third step of His biosynthesis.<ref>PMID:22741521</ref>  


== Disease ==
== Disease ==


== Relevance ==
Mutations in GTP cyclohydrolase I are associated with malignant phenylketonuria, hyperphenylalaninemia and DOPA-responsive dystonia.


== Structural highlights ==
== Structural highlights ==
<scene name='59/595207/Cv/7'>GTP cyclohydrolase I</scene> from ''Escherichia coli'' ([[1n3r]]) is pentamer. <scene name='59/595207/Cv/8'>GCH I GTP binding pocket</scene> at the intersubunit interface.<ref>PMID:12559918</ref> <scene name='59/595207/Cv/9'>Surface representation of GCH I GTP binding pocket</scene>.


==3D structures of cyclohydrolase==
==3D structures of cyclohydrolase==
[[Cyclohydrolase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*GTP cyclohydrolase I
 
**[[1gtp]] – EcGCH I – ''Escherichia coli''<br />
**[[3d1t]] – NgGCH IB + Zn – ''Neisseria gonorrhoeae''<br />
**[[3d2o]] – NgGCH IB + Mn<br />
**[[1fb1]] – hGCH I + Zn – human<br />
**[[1wm9]] – TtGCH I + Zn – ''Thermus thermophilus''<br />
 
*''GTP cyclohydrolase I complexes''
 
**[[1a8r]], [[1a9c]], [[1n3r]], [[1n3t]], [[1n3s]] – EcGCH I (mutant) + GTP <br />
**[[4du6]] – GCH I + GTP – ''Yersinia pseudotuberculosis''<br />
**[[1fbx]] – EcGCH I + Zn <br />
**[[1wuq]], [[1wur]] – TtGCH I + Zn + 8-oxo-GTP <br />
**[[1is7]] – rGCH I + GCH feedback regulatory protein - rat<br />
**[[1is8]] – rGCH I + GCH feedback regulatory protein + Zn<br />
**[[1wpl]] – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin<br />
 
*GTP cyclohydrolase II
 
**[[2bz1]] – EcGCH II + Zn <br />
**[[2bz0]] – EcGCH II + Zn + phosphomethylphosphonic acid guanylate<br />
 
*GTP cyclohydrolase III
 
**[[2qv6]] – GCH III + GTP + Ca – ''Methanocaldococcus jannaschii'' <br />
 
*IMP cyclohydrolase
 
**[[2ntm]] – MtICH – ''Methanothermobacter thermoautotrophicus''<br />
**[[2ntk]] – MtICH + IMP <br />
**[[2ntl]] – MtICH + AICAR<br />
 
*Methenyltetrahydromethanopterin cyclohydrolase
 
**[[1qlm]] – MCH – ''Methanopyrus kandleri''<br />
**[[4gvr]] – AfMCH – ''Archaeoglobus fulgidus''<br />
**[[4gvq]] – AfMCH + tetrahydromethanopterin <br />
**[[4gvs]] – AfMCH + N5-formyl-tetrahydromethanopterin <br />
 
*Phosphoribosyl-ATP cyclohydrolase
 
**[[1zps]] – MtPCH + Cd <br />
}}


== References ==
== References ==

Latest revision as of 10:26, 9 June 2024

Structure of GTP cyclohydrolase I pentamer complex with GTP (PDB code 1n3r).

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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