1lmz: Difference between revisions

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[[Image:1lmz.gif|left|200px]]


{{Structure
==Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)==
|PDB= 1lmz |SIZE=350|CAPTION= <scene name='initialview01'>1lmz</scene>
<StructureSection load='1lmz' size='340' side='right'caption='[[1lmz]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1lmz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LMZ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_I DNA-3-methyladenine glycosylase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.20 3.2.2.20]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= TAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmz OCA], [https://pdbe.org/1lmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lmz RCSB], [https://www.ebi.ac.uk/pdbsum/1lmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmz ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/3MG1_ECOLI 3MG1_ECOLI] Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/1lmz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lmz ConSurf].
<div style="clear:both"></div>


'''Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)'''
==See Also==
 
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The Escherichia coli enzyme 3-methyladenine DNA glycosylase I (TAG) hydrolyzes the glycosidic bond of 3-methyladenine (3-MeA) in DNA and is found in many bacteria and some higher eukaryotes. TAG shows little primary sequence identity with members of the well-known helix-hairpin-helix (HhH) superfamily of DNA repair glycosylases, which consists of AlkA, EndoIII, MutY and hOGG1. Unexpectedly, the three-dimensional solution structure reported here reveals TAG as member of this superfamily. The restricted specificity of TAG for 3-MeA bases probably arises from its unique aromatic rich 3-MeA binding pocket and the absence of a catalytic aspartate that is present in all other HhH family members.
[[Category: Escherichia coli B]]
 
[[Category: Large Structures]]
==About this Structure==
[[Category: Drohat AC]]
1LMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMZ OCA].
[[Category: Krosky DJ]]
 
[[Category: Kwon K]]
==Reference==
[[Category: Stivers JT]]
3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member., Drohat AC, Kwon K, Krosky DJ, Stivers JT, Nat Struct Biol. 2002 Sep;9(9):659-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12161745 12161745]
[[Category: DNA-3-methyladenine glycosylase I]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Drohat, A C.]]
[[Category: Krosky, D J.]]
[[Category: Kwon, K.]]
[[Category: Stivers, J T.]]
[[Category: 3-methyladenine]]
[[Category: dna glycosylase]]
[[Category: enzyme]]
[[Category: helix-hairpin-helix superfamily]]
[[Category: nmr spectroscopy]]
[[Category: solution structure]]
[[Category: tag]]
 
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Retrieved from "https://proteopedia.org/1lmz"