Ficolin: Difference between revisions
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<StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '> | |||
== Function == | |||
'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>. 3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''. | |||
*'''Fiicolin-1''' or '''M-ficolin''' is a pattern recognition molecule of the complement system expressed in myeloid cells<ref>PMID:18343499</ref>. | |||
== Disease == | |||
Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>. | |||
== Structural highlights == | |||
<scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>. | |||
<scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of Ficolin == | == 3D Structures of Ficolin == | ||
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*L-ficolin | *L-ficolin | ||
**[[2j3g]] - hL-Fic binding domain<br /> | **[[2j3g]], [[4r9t]] - hL-Fic binding domain<br /> | ||
**[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br /> | **[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br /> | ||
**[[2j0h]] - hL-Fic binding domain + acetylcholine<br /> | **[[2j0h]] - hL-Fic binding domain + acetylcholine<br /> | ||
**[[4nyt]] - hL-Fic binding domain + phosphocholine<br /> | |||
**[[2j0y]] - hL-Fic binding domain + glucan<br /> | **[[2j0y]] - hL-Fic binding domain + glucan<br /> | ||
**[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br /> | **[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br /> | ||
**[[2j3f]] - hL-Fic binding domain + galactosamine<br /> | **[[2j3f]] - hL-Fic binding domain + galactosamine<br /> | ||
**[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br /> | **[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br /> | ||
**[[4r9j]] - hL-Fic binding domain + glucosamine sulfate<br /> | |||
**[[2j3u]] - hL-Fic binding domain + galactose<br /> | **[[2j3u]] - hL-Fic binding domain + galactose<br /> | ||
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== References == | |||
<references/> | |||
Latest revision as of 08:00, 23 June 2024
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3D Structures of Ficolin
Updated on 23-June-2024
