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[[Image:1m11.gif|left|200px]]


{{Structure
==structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy==
|PDB= 1m11 |SIZE=350|CAPTION= <scene name='initialview01'>1m11</scene>, resolution 16.0&Aring;
<SX load='1m11' size='340' side='right' viewer='molstar' caption='[[1m11]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1m11]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_E7 Echovirus E7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M11 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m11 OCA], [https://pdbe.org/1m11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m11 RCSB], [https://www.ebi.ac.uk/pdbsum/1m11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m11 ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m11_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m11 ConSurf].
<div style="clear:both"></div>


'''structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy'''
==See Also==
 
*[[CD55|CD55]]
 
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
==Overview==
== References ==
Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electron microscopy reconstructions of echovirus 7 complexed with DAF show that the DAF-binding regions are located close to the icosahedral twofold axes, in contrast to other enterovirus complexes where the viral canyon is the receptor binding site. This novel receptor binding position suggests that DAF is important for the attachment of viral particles to host cells, but probably not for initiating viral uncoating, as is the case with canyon-binding receptors. Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF.
<references/>
 
__TOC__
==Disease==
</SX>
Known diseases associated with this structure: Blood group Cromer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=125240 125240]], Blood group, Knops system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], CR1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], Malaria, severe, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], SLE susceptibility OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]]
[[Category: Echovirus E7]]
 
==About this Structure==
1M11 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_6 Human echovirus 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA].
 
==Reference==
Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex., He Y, Lin F, Chipman PR, Bator CM, Baker TS, Shoham M, Kuhn RJ, Medof ME, Rossmann MG, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10325-9. Epub 2002 Jul 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12119400 12119400]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human echovirus 6]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Baker TS]]
[[Category: Baker, T S.]]
[[Category: Bator CM]]
[[Category: Bator, C M.]]
[[Category: Chipman PR]]
[[Category: Chipman, P R.]]
[[Category: He Y]]
[[Category: He, Y.]]
[[Category: Kuhn RJ]]
[[Category: Kuhn, R J.]]
[[Category: Lin F]]
[[Category: Lin, F.]]
[[Category: Medof ME]]
[[Category: Medof, M E.]]
[[Category: Rossmann MG]]
[[Category: Rossmann, M G.]]
[[Category: Shoham M]]
[[Category: Shoham, M.]]
[[Category: decay-accelerating factor]]
[[Category: icosahedral virus]]
[[Category: scr]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:37:32 2008''

Latest revision as of 07:38, 14 February 2024

structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy

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