Parvalbumin: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Pike parvalbumin complex with Ca+2 ions (green), ammonium ion (blue), acetyl and formate (PDB entry [[2pvb]])' scene='46/466520/Cv/2' pspeed='8'> | |||
== Function == | |||
'''Parvalbumin (PVA)''' is a calcium-binding albumin protein. PVA is involved in calcium signaling<ref>PMID:11867433</ref>. PVA contains 3 domains each containing 2 helices: AB, CD (N-terminal) and EF (C-terminal). '''α-parvalbumin''' differs from '''β-parvalbumin''' in 54 positions. α-parvalbumin is expressed in various tissues while β-parvalbumin is expressed only in preterm placenta<ref>PMID:8354278</ref>. <br /> | |||
See also<br /> | |||
* [[EF hand]] | |||
* [[Parvalbumin carp]]. | |||
== Relevance == | |||
PVA is a major fish allergen<ref>PMID:18221468</ref>. | |||
== Structural highlights == | |||
PVA contains a <scene name='46/466520/Cv/10'>heptacoordinated Ca+2 ion binding to 7 oxygen atoms</scene> in a <scene name='46/466520/Cv/11'>typical EF-hand</scene> coordination<ref>PMID:10548066</ref>. Water molecules are shown as red spheres. <scene name='46/466520/Cv/12'>Calcium ion is coordinated by seven oxygen atoms that form a pentagonal bipyramid </scene>. | |||
*<scene name='46/466520/Cv/13'>Ammonium ion coordination site</scene>. | |||
</StructureSection> | |||
== 3D Structures of Parvalbumin == | == 3D Structures of Parvalbumin == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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**[[1pal]], [[2pal]], [[3pal]], [[4pal]], [[1pvb]], [[1pva]], [[2pvb]] – pPVA – pike<br /> | **[[1pal]], [[2pal]], [[3pal]], [[4pal]], [[1pvb]], [[1pva]], [[2pvb]] – pPVA – pike<br /> | ||
**[[2pas]], [[3pat]] – pPVA – NMR<br /> | **[[2pas]], [[3pat]] – pPVA – NMR<br /> | ||
**[[1a75]] – PVA – whiting | **[[1a75]] – PVA – whiting<br /> | ||
**[[1bu3]] – PVA Ca-binding domain – hake<br /> | |||
**[[5zgm]] – MgPVA SPV-I – ''Mustelus griseus''<br /> | |||
**[[5zh6]] – MgPVA SPV-II<br /> | |||
*α-parvalbumin | *α-parvalbumin | ||
**[[ | **[[1rjv]], [[1rk9]] - hPVA-α - human – NMR<br /> | ||
**[[9bb8]] - hPVA-alpha | |||
**[[1rtp]], [[1rwy]] - rPVA-α - rat<br /> | **[[1rtp]], [[1rwy]] - rPVA-α - rat<br /> | ||
**[[2jww]] - rPVA-α Ca-free – NMR<br /> | **[[2jww]] - rPVA-α Ca-free – NMR<br /> | ||
**[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br /> | **[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br /> | ||
**[[ | **[[5pal]] – PVA-α - shark<br /> | ||
**[[9bar]] - PVA-alpha - ray | |||
*β-parvalbumin (oncomodulin) | *β-parvalbumin (oncomodulin) | ||
**[[1ttx]] - hPVA-β (mutant) – NMR<br /> | |||
**[[2nln]] - rPVA-β Ca-free – NMR<br /> | **[[2nln]] - rPVA-β Ca-free – NMR<br /> | ||
**[[1rro]], [[1omd]] - rPVA-β <br /> | **[[1rro]], [[1omd]] - rPVA-β <br /> | ||
**[[3fs7]] - chPVA-β - chicken<br /> | **[[3fs7]] - chPVA-β - chicken<br /> | ||
**[[2kqy]] – chPVA-β – NMR<br /> | **[[2kqy]] – chPVA-β – NMR<br /> | ||
**[[2kyc]] - chPVA-β <br /> | **[[2kyc]] - chPVA-β <br /> | ||
**[[2kyf]] - chPVA-β (mutant) – NMR | **[[2kyf]] - chPVA-β (mutant) – NMR<br /> | ||
**[[2mbx]] - coPVA-β – cod - NMR<br /> | |||
**[[9b26]] - coPVA-beta | |||
**[[5xnd]] - PVA-β – mackerel - NMR<br /> | |||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 10:00, 19 April 2026
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3D Structures of Parvalbumin
Updated on 19-April-2026
