4oww: Difference between revisions
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==Structural basis of SOSS1 in complex with a 35nt ssDNA== | ==Structural basis of SOSS1 in complex with a 35nt ssDNA== | ||
<StructureSection load='4oww' size='340' side='right' caption='[[4oww]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4oww' size='340' side='right'caption='[[4oww]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4oww]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4oww]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OWW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oww OCA], [https://pdbe.org/4oww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oww RCSB], [https://www.ebi.ac.uk/pdbsum/4oww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oww ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/INT3_HUMAN INT3_HUMAN] Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4oww" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Ren | [[Category: Large Structures]] | ||
[[Category: Song | [[Category: Ren W]] | ||
[[Category: Sun | [[Category: Song H]] | ||
[[Category: Tang | [[Category: Sun Q]] | ||
[[Category: Tang X]] | |||
