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==17beta-HSD1 in complex with A-diol==
==17beta-HSD1 in complex with A-diol==
<StructureSection load='3klp' size='340' side='right' caption='[[3klp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3klp' size='340' side='right'caption='[[3klp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3klp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLP FirstGlance]. <br>
<table><tr><td colspan='2'>[[3klp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B81:(3ALPHA,8ALPHA,17BETA)-ANDROST-5-ENE-3,17-DIOL'>B81</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B81:(3ALPHA,8ALPHA,17BETA)-ANDROST-5-ENE-3,17-DIOL'>B81</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3klp RCSB], [http://www.ebi.ac.uk/pdbsum/3klp PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klp OCA], [https://pdbe.org/3klp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3klp RCSB], [https://www.ebi.ac.uk/pdbsum/3klp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3klp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.


==See Also==
==See Also==
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Estradiol 17-beta-dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lin, S X]]
[[Category: Large Structures]]
[[Category: Mazumdar, M]]
[[Category: Lin S-X]]
[[Category: Dehydrogenase]]
[[Category: Mazumdar M]]
[[Category: Oxidoreductase]]
[[Category: Protein-ligand complex]]
Retrieved from "https://proteopedia.org/3klp"