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==Crystal Structure Analysis of H207F Mutant of Human CLIC1==
==Crystal Structure Analysis of H207F Mutant of Human CLIC1==
<StructureSection load='3p90' size='340' side='right' caption='[[3p90]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3p90' size='340' side='right'caption='[[3p90]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3p90]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P90 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3p90]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P90 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p8w|3p8w]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLIC1, G6, NCC27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p90 OCA], [https://pdbe.org/3p90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p90 RCSB], [https://www.ebi.ac.uk/pdbsum/3p90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p90 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p90 RCSB], [http://www.ebi.ac.uk/pdbsum/3p90 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3p90" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ion channels|Ion channels]]
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Achilonu, I A]]
[[Category: Large Structures]]
[[Category: Cross, M O]]
[[Category: Achilonu IA]]
[[Category: Dirr, H W]]
[[Category: Cross MO]]
[[Category: Fanucchi, S]]
[[Category: Dirr HW]]
[[Category: Fernandes, M A]]
[[Category: Fanucchi S]]
[[Category: Clic]]
[[Category: Fernandes MA]]
[[Category: Glutathione transferase]]
[[Category: Ion channel]]
[[Category: Ph sensor]]
[[Category: Thioredoxin]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/3p90"