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==Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor==
==Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor==
<StructureSection load='3smj' size='340' side='right' caption='[[3smj]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3smj' size='340' side='right'caption='[[3smj]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3smj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3smj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SMJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDR:2-METHYL-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE'>FDR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3goy|3goy]], [[3se2|3se2]], [[3smi|3smi]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDR:2-METHYL-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE'>FDR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAL2, KIAA1268, PARP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3smj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smj OCA], [https://pdbe.org/3smj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3smj RCSB], [https://www.ebi.ac.uk/pdbsum/3smj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3smj ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3smj RCSB], [http://www.ebi.ac.uk/pdbsum/3smj PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3smj" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Berglund, H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Berglund H]]
[[Category: Edwards, A M]]
[[Category: Bountra C]]
[[Category: Ekblad, T]]
[[Category: Edwards AM]]
[[Category: Graslund, S]]
[[Category: Ekblad T]]
[[Category: Karlberg, T]]
[[Category: Graslund S]]
[[Category: Kouznetsova, E]]
[[Category: Karlberg T]]
[[Category: Moche, M]]
[[Category: Kouznetsova E]]
[[Category: Nordlund, P]]
[[Category: Moche M]]
[[Category: Nyman, T]]
[[Category: Nordlund P]]
[[Category: Structural genomic]]
[[Category: Nyman T]]
[[Category: Schuler, H]]
[[Category: Schuler H]]
[[Category: Thorsell, A G]]
[[Category: Thorsell AG]]
[[Category: Tresaugues, L]]
[[Category: Tresaugues L]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Adp-ribosylation]]
[[Category: Diphtheria toxin like fold]]
[[Category: Nad+]]
[[Category: Sgc]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/3smj"