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==WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP==
==WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP==
<StructureSection load='4dpd' size='340' side='right' caption='[[4dpd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4dpd' size='340' side='right'caption='[[4dpd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4dpd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DPD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4dpd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DPD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j3i|1j3i]], [[2qgt|2qgt]], [[3dga|3dga]], [[4dp3|4dp3]], [[4dph|4dph]], [[4ddr|4ddr]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpd OCA], [https://pdbe.org/4dpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dpd RCSB], [https://www.ebi.ac.uk/pdbsum/4dpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dpd ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dpd RCSB], [http://www.ebi.ac.uk/pdbsum/4dpd PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A7UD81_PLAFA A7UD81_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4dpd" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydrofolate reductase]]
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Arwon, U]]
[[Category: Arwon U]]
[[Category: Bongard, E]]
[[Category: Bongard E]]
[[Category: Charman, S A]]
[[Category: Charman SA]]
[[Category: Charman, W N]]
[[Category: Charman WN]]
[[Category: Chitnumsub, P]]
[[Category: Chitnumsub P]]
[[Category: Fantauzzi, P]]
[[Category: Fantauzzi P]]
[[Category: Kamchonwongpaisan, S]]
[[Category: Kamchonwongpaisan S]]
[[Category: Matthews, D]]
[[Category: Matthews D]]
[[Category: McLennan, D N]]
[[Category: McLennan DN]]
[[Category: Tarnchompoo, B]]
[[Category: Tarnchompoo B]]
[[Category: Taweechai, S]]
[[Category: Taweechai S]]
[[Category: Thongphanchang, C]]
[[Category: Thongphanchang C]]
[[Category: Vanichtanakul, J]]
[[Category: Vanichtanakul J]]
[[Category: Vilaivan, T]]
[[Category: Vilaivan T]]
[[Category: Vivas, L]]
[[Category: Vivas L]]
[[Category: White, K L]]
[[Category: White KL]]
[[Category: Yuthavong, Y]]
[[Category: Yuthavong Y]]
[[Category: Yuvaniyama, J]]
[[Category: Yuvaniyama J]]
[[Category: Dhfr]]
[[Category: Nadph binding]]
[[Category: Oxidoreductase]]
[[Category: Reductase]]
[[Category: Rossmann fold]]
[[Category: Transferase]]
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