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==LytR-CPS2A-Psr family protein with bound octaprenyl pyrophosphate lipid and manganese ion==
==LytR-CPS2A-Psr family protein with bound octaprenyl pyrophosphate lipid and manganese ion==
<StructureSection load='3tel' size='340' side='right' caption='[[3tel]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3tel' size='340' side='right'caption='[[3tel]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TEL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TEL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZTP:(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>ZTP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">wzg, SPC02_0004 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZTP:(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>ZTP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tel RCSB], [http://www.ebi.ac.uk/pdbsum/3tel PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tel OCA], [https://pdbe.org/3tel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tel RCSB], [https://www.ebi.ac.uk/pdbsum/3tel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tel ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q4K376_STREE Q4K376_STREE]
Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall.
 
A widespread family of bacterial cell wall assembly proteins.,Kawai Y, Marles-Wright J, Cleverley RM, Emmins R, Ishikawa S, Kuwano M, Heinz N, Bui NK, Hoyland CN, Ogasawara N, Lewis RJ, Vollmer W, Daniel RA, Errington J EMBO J. 2011 Sep 30. doi: 10.1038/emboj.2011.358. PMID:21964069<ref>PMID:21964069</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
[[Category: Bui, N Khai]]
[[Category: Cleverley RM]]
[[Category: Cleverley, R M]]
[[Category: Daniel RA]]
[[Category: Daniel, R A]]
[[Category: Emmins R]]
[[Category: Emmins, R]]
[[Category: Errington J]]
[[Category: Errington, J]]
[[Category: Heinz N]]
[[Category: Heinz, N]]
[[Category: Hoyland CN]]
[[Category: Hoyland, C N]]
[[Category: Ishikawa S]]
[[Category: Ishikawa, S]]
[[Category: Kawai Y]]
[[Category: Kawai, Y]]
[[Category: Khai Bui N]]
[[Category: Kuwano, M]]
[[Category: Kuwano M]]
[[Category: Lewis, R J]]
[[Category: Lewis RJ]]
[[Category: Marles-Wright, J]]
[[Category: Marles-Wright J]]
[[Category: Ogasawara, N]]
[[Category: Ogasawara N]]
[[Category: Vollmer, W]]
[[Category: Vollmer W]]
[[Category: Cell wall techoic acid synthesis]]
[[Category: Replication]]
[[Category: Transferase]]

Latest revision as of 10:08, 1 March 2024

LytR-CPS2A-Psr family protein with bound octaprenyl pyrophosphate lipid and manganese ion

3tel, resolution 1.80Å

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