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==Crystal structure of KANK2 ankyrin repeats==
==Crystal structure of KANK2 ankyrin repeats==
<StructureSection load='4hbd' size='340' side='right' caption='[[4hbd]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
<StructureSection load='4hbd' size='340' side='right'caption='[[4hbd]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KANK2, ANKRD25, KIAA1518, MXRA3, SIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [https://pdbe.org/4hbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [https://www.ebi.ac.uk/pdbsum/4hbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref>
==See Also==
*[[Ankyrin repeat domain-containing protein 3D structures|Ankyrin repeat domain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bakkouri, M El]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Cerovina, T]]
[[Category: Cerovina T]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Min, J]]
[[Category: El Bakkouri M]]
[[Category: Structural genomic]]
[[Category: Min J]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Xu, C]]
[[Category: Xu C]]
[[Category: Protein binding]]
[[Category: Sgc]]
Retrieved from "https://proteopedia.org/4hbd"