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==Crystal structure of SeMet derivative of HMP synthase Thi5 from S. cerevisiae==
==Crystal structure of SeMet derivative of HMP synthase Thi5 from S. cerevisiae==
<StructureSection load='4h65' size='340' side='right' caption='[[4h65]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4h65' size='340' side='right'caption='[[4h65]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h65]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H65 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h65]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H65 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h67|4h67]], [[4h6d|4h6d]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THI5, YFL058W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h65 OCA], [https://pdbe.org/4h65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h65 RCSB], [https://www.ebi.ac.uk/pdbsum/4h65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h65 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h65 RCSB], [http://www.ebi.ac.uk/pdbsum/4h65 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THI5_YEAST THI5_YEAST] Proposed biosynthetic enzyme involved in pyrimidine biosynthesis pathway above the hydroxymethyl-pyrimidine precursor leading to the thiamine moiety.<ref>PMID:12777485</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4h65" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Coquille, S C]]
[[Category: Coquille SC]]
[[Category: Fitzpatrick, T]]
[[Category: Fitzpatrick T]]
[[Category: Roux, C]]
[[Category: Roux C]]
[[Category: Thore, S]]
[[Category: Thore S]]
[[Category: Hmp-p synthase]]
[[Category: Plp binding]]
[[Category: Thi5-plp complex]]
[[Category: Transferase]]
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