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| | <StructureSection load='' size='350' side='right' scene='54/540162/Cv/1' caption='Shikimate dehydrogenase dimer complex with shikimate, sulfate and NADP [[2ev9]]'> |
| | __TOC__ |
| | == Function == |
| | '''Shikimate dehydrogenase''' (AroE) catalyzes the conversion of shikimate and NADP+ to 3-dihydroshikimate, NADPH and H+. It is part of the shikimate pathway which is responsible for the biosynthesis of phenylalanine, tyrosine and tryptophan. This pathway is found in bacteria, fungi, plants, algae and parasites and is missing in animals and humans<ref>PMID:18669580</ref>. |
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| {{STRUCTURE_2ev9| PDB=2ev9 | SIZE=350| SCENE= |right|CAPTION=Shikimate dehydrogenase dimer complex with shikimate, sulfate and NADP [[2ev9]] }}
| | ==Structural highlights == |
| | | AroE changes its conformation from an open to closed one upon binding of the cofactor NADP. The active site contains the substrate shikimate<ref>PMID:17825835</ref>. |
| '''Shikimate dehydrogenase''' (AroE) catalyzes the conversion of shikimate and NADP+ to 3-dihydroshikimate, NADPH and H+. It is part of the shikimate pathway which is responsible for the biosynthesis of phenylalanine, tyrosine and tryptophan. This pathway is found in bacteria, fungi, plants, algae and parasites and is missing in animals and humans.
| | *<scene name='54/540162/Cv/5'>NADP binding site</scene>. Water molecules are shown as red spheres. |
| | *<scene name='54/540162/Cv/6'>Whole binding site</scene>. |
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| == 3D Structures of shikimate dehydrogenase == | | == 3D Structures of shikimate dehydrogenase == |
| | | [[Shikimate dehydrogenase 3D structures]] |
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | == References == |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| | </StructureSection> |
| | | <references/> |
| *Shikimate dehydrogenase
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| **[[1p74]], [[1p77]] – AroE – ''Haemophilus influenzae''<br />
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| **[[1wxd]] – TtAroE – ''Thermus thermophilus'' <br />
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| **[[2hk7]], [[2hk8]] – AaAroE – ''Aquifex aeolicus'' <br />
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| **[[2egg]] – AroE – ''Geobacillus kaustophilus'' <br />
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| **[[3fbt]] – AroE/chorismate mutase – ''Clostridium acetobutylicum'' <br />
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| **[[3don]] – SeAroE – ''Staphylococcus epidermidis'' <br />
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| **[[3o8q]] – VcAroE – ''Vibrio cholerae'' <br />
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| **[[3pwz]] – AroE 3 – ''Pseudomonas putida'' <br />
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| **[[3phg]] – HpAroE – ''Helicobacter pylori'' <br />
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| **[[4foo]], [[4fpx]] – HpAroE (mutant) <br />
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| **[[3u62]] – AroE – ''Thermotoga maritima'' <br />
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| **[[2nlo]] – CgAroE – ''Corynebacterium glutamicum''<br />
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| *Shikimate dehydrogenase complex with NADP
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| **[[1nyt]], [[1vi2]] – EcAroE + NADP – ''Escherichia coli''<br />
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| **[[1nvt]] – MjAroE + NADP – ''Methanocaldococcus jannaschii''<br />
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| **[[2cy0]] – TtAroE + NADP <br />
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| **[[3toz]] – LmAroE + NAD – ''Listeria monocytogenes''<br />
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| **[[3t4e]] – AroE + NAD – ''Salmonella enterica''<br />
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| **[[3jyo]] - CgAroE + NAD <br />
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| *Shikimate dehydrogenase complex with shikimate
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| **[[2d5c]] – TtAroE + shikimate <br />
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| **[[3doo]] – SeAroE + shikimate <br />
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| **[[3pgj]] – VcAroE + shikimate <br />
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| **[[3phh]] – HpAroE + shikimate <br />
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| **[[4fos]], [[4fq8]], [[4fr5]], [[4fsh]] – HpAroE (mutant) + shikimate <br />
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| **[[3phj]] – HpAroE + 3-dihydroshikimate <br />
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| *Shikimate dehydrogenase complex with NADP and shikimate
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| **[[2ev9]] – TtAroE + shikimate + NADP <br />
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| **[[2hk9]] – AaAroE + shikimate + NADP <br />
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| **[[3sef]] – VcAroE + shikimate + NADP <br />
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| **[[3tnl]] – LmAroE + shikimate + NAD <br />
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| **[[3phi]] – HpAroE + shikimate + NADP <br />
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| **[[3jyp]] - CgAroE + quinate + NAD <br />
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| **[[3jyq]] - CgAroE + shikimate + NAD <br />
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| }}
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
