4x5f: Difference between revisions
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New page: '''Unreleased structure''' The entry 4x5f is ON HOLD Authors: Yamada, H., Watanabe, N., Nagae, T. Description: ecDHFR complexed with folate and NADP+ at 0.1 MPa |
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==ecDHFR complexed with folate and NADP+ at 0.1 MPa== | |||
<StructureSection load='4x5f' size='340' side='right'caption='[[4x5f]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4x5f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X5F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x5f OCA], [https://pdbe.org/4x5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x5f RCSB], [https://www.ebi.ac.uk/pdbsum/4x5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x5f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==See Also== | |||
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Nagae T]] | |||
[[Category: Watanabe N]] | |||
[[Category: Yamada H]] | |||
Latest revision as of 06:53, 3 April 2024
ecDHFR complexed with folate and NADP+ at 0.1 MPa
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