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==Crystal structure of Lycorine bound to the yeast 80S ribosome==
==Crystal structure of Lycorine bound to the yeast 80S ribosome==
<StructureSection load='4u4u' size='340' side='right' caption='[[4u4u]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4u4u' size='340' side='right'caption='[[4u4u]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4u4u]] is a 162 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_atcc_204508_/_s288c Saccharomyces cerevisiae atcc 204508 / s288c]. This structure supersedes the now removed PDB entries  and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ujo 4ujo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4u4u]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3KD:(1S,2S,12BS,12CS)-2,4,5,7,12B,12C-HEXAHYDRO-1H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL'>3KD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3KD:(1S,2S,12BS,12CS)-2,4,5,7,12B,12C-HEXAHYDRO-1H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL'>3KD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ujk|4ujk]], [[4ujl|4ujl]], [[4ujm|4ujm]], [[4ujn|4ujn]], [[4ujo|4ujo]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4u OCA], [https://pdbe.org/4u4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4u RCSB], [https://www.ebi.ac.uk/pdbsum/4u4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4u RCSB], [http://www.ebi.ac.uk/pdbsum/4u4u PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL28_YEAST RL28_YEAST]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4u4u" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Saccharomyces cerevisiae atcc 204508 / s288c]]
[[Category: Large Structures]]
[[Category: Loubresse, N Garreau de]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Prokhorova, I]]
[[Category: Garreau de Loubresse N]]
[[Category: Yusupov, M]]
[[Category: Prokhorova I]]
[[Category: Yusupova, G]]
[[Category: Yusupov M]]
[[Category: Antibiotic]]
[[Category: Yusupova G]]
[[Category: Eukaryote]]
[[Category: Inhibitor]]
[[Category: Ribosome]]
[[Category: Rna-protein complex]]
[[Category: Translation]]

Latest revision as of 16:49, 25 September 2026

Crystal structure of Lycorine bound to the yeast 80S ribosome

4u4u, resolution 3.00Å

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