3x22: Difference between revisions
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New page: '''Unreleased structure''' The entry 3x22 is ON HOLD Authors: Bai, J., Yang, J., Zhou, Y., Yang, Q. Description: Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F... |
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==Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W== | |||
<StructureSection load='3x22' size='340' side='right'caption='[[3x22]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3x22]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X22 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.001Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x22 OCA], [https://pdbe.org/3x22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x22 RCSB], [https://www.ebi.ac.uk/pdbsum/3x22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x22 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NFSB_ECOLI NFSB_ECOLI] Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.<ref>PMID:15684426</ref> | |||
==See Also== | |||
*[[Nitroreductase 3D structures|Nitroreductase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Bai J]] | |||
[[Category: Yang J]] | |||
[[Category: Yang Q]] | |||
[[Category: Zhou Y]] | |||
Latest revision as of 13:39, 8 November 2023
Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W
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