1p9k: Difference between revisions

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[[Image:1p9k.gif|left|200px]]


{{Structure
==THE SOLUTION STRUCTURE OF YBCJ FROM E. COLI REVEALS A RECENTLY DISCOVERED ALFAL MOTIF INVOLVED IN RNA-BINDING==
|PDB= 1p9k |SIZE=350|CAPTION= <scene name='initialview01'>1p9k</scene>
<StructureSection load='1p9k' size='340' side='right'caption='[[1p9k]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1p9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1o09 1o09]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9K FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= ybcJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9k OCA], [https://pdbe.org/1p9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9k RCSB], [https://www.ebi.ac.uk/pdbsum/1p9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9k ProSAT], [https://www.topsan.org/Proteins/BSGI/1p9k TOPSAN]</span></td></tr>
}}
</table>
 
== Function ==
'''THE SOLUTION STRUCTURE OF YBCJ FROM E. COLI REVEALS A RECENTLY DISCOVERED ALFAL MOTIF INVOLVED IN RNA-BINDING'''
[https://www.uniprot.org/uniprot/YBCJ_ECOLI YBCJ_ECOLI] Its structure and the presence of conserved basic residues indicates that it probably binds RNA.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The structure of the recombinant Escherichia coli protein YbcJ, a representative of a conserved family of bacterial proteins (COG2501), was determined by nuclear magnetic resonance. The fold of YbcJ identified it as a member of the larger family of S4-like RNA binding domains. These domains bind to structured RNA, such as that found in tRNA, rRNA, and a pseudoknot of mRNA. The structure of YbcJ revealed a highly conserved patch of basic residues, comprising amino acids K26, K38, R55, K56, and K59, which likely participate in RNA binding.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p9k_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1P9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry 1O09. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9K OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p9k ConSurf].
The solution structure of YbcJ from Escherichia coli reveals a recently discovered alphaL motif involved in RNA binding., Volpon L, Lievre C, Osborne MJ, Gandhi S, Iannuzzi P, Larocque R, Cygler M, Gehring K, Ekiel I, J Bacteriol. 2003 Jul;185(14):4204-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837795 12837795]
<div style="clear:both"></div>
[[Category: Escherichia coli]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
[[Category: Escherichia coli K-12]]
[[Category: Cygler, M.]]
[[Category: Large Structures]]
[[Category: Ekiel, I.]]
[[Category: Cygler M]]
[[Category: Gandhi, S.]]
[[Category: Ekiel I]]
[[Category: Gehring, K.]]
[[Category: Gandhi S]]
[[Category: Iannuzzi, P.]]
[[Category: Gehring K]]
[[Category: Larocque, R.]]
[[Category: Iannuzzi P]]
[[Category: Lievre, C.]]
[[Category: Larocque R]]
[[Category: Matte, A.]]
[[Category: Lievre C]]
[[Category: Osborne, M J.]]
[[Category: Matte A]]
[[Category: Volpon, L.]]
[[Category: Osborne MJ]]
[[Category: alfal motif]]
[[Category: Volpon L]]
[[Category: bsgi]]
[[Category: e coli]]
[[Category: montreal-kingston bacterial structural genomics initiative]]
[[Category: rna-binding protein]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:41 2008''

Latest revision as of 05:53, 17 April 2024

THE SOLUTION STRUCTURE OF YBCJ FROM E. COLI REVEALS A RECENTLY DISCOVERED ALFAL MOTIF INVOLVED IN RNA-BINDING

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