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==Crystal Structure of the Epstein-Barr virus gH and gL complex==
==Crystal Structure of the Epstein-Barr virus gH and gL complex==
<StructureSection load='3phf' size='340' side='right' caption='[[3phf]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
<StructureSection load='3phf' size='340' side='right'caption='[[3phf]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3phf]] is a 32 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHF FirstGlance]. <br>
<table><tr><td colspan='2'>[[3phf]] is a 32 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHF FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m1c|3m1c]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.58&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BXLF2, gH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 Human herpesvirus 4]), BKRF2, GL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 Human herpesvirus 4])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phf OCA], [https://pdbe.org/3phf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phf RCSB], [https://www.ebi.ac.uk/pdbsum/3phf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3phf RCSB], [http://www.ebi.ac.uk/pdbsum/3phf PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GL_EBVB9 GL_EBVB9] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. May also be required for virus attachment to epithelial cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3phf" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human herpesvirus 4]]
[[Category: Human gammaherpesvirus 4]]
[[Category: Jardetzky, T S]]
[[Category: Large Structures]]
[[Category: Kirschner, A N]]
[[Category: Jardetzky TS]]
[[Category: Matsuura, H]]
[[Category: Kirschner AN]]
[[Category: Glycoprotein]]
[[Category: Matsuura H]]
[[Category: Membrane fusion]]
[[Category: Viral protein]]
[[Category: Virus entry]]