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==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
<StructureSection load='3pip' size='340' side='right' caption='[[3pip]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
<StructureSection load='3pip' size='340' side='right'caption='[[3pip]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3pip]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PIP FirstGlance]. <br>
<table><tr><td colspan='2'>[[3pip]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PIP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LC2:N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-DIHYDROXY-1,4,10,19-TETRAMETHYL-17,18-DIOXO-16-OXABICYCLO[13.2.2]NONADECA-3,5,9,11-TETRAEN-2-YL]-2-OXOPROPANAMIDE'>LC2</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zjr|2zjr]], [[1nkw|1nkw]], [[1sm1|1sm1]], [[3jq4|3jq4]], [[1yi2|1yi2]], [[3pio|3pio]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LC2:N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-DIHYDROXY-1,4,10,19-TETRAMETHYL-17,18-DIOXO-16-OXABICYCLO[13.2.2]NONADECA-3,5,9,11-TETRAEN-2-YL]-2-OXOPROPANAMIDE'>LC2</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pip RCSB], [http://www.ebi.ac.uk/pdbsum/3pip PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pip OCA], [https://pdbe.org/3pip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pip RCSB], [https://www.ebi.ac.uk/pdbsum/3pip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pip ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL11_DEIRA RL11_DEIRA] This protein binds directly to 23S ribosomal RNA and also contacts the CTC protein (RL25).[HAMAP-Rule:MF_00736_B]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3pip" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans r1]]
[[Category: Deinococcus radiodurans R1]]
[[Category: Bashan, A]]
[[Category: Large Structures]]
[[Category: Belousoff, M J]]
[[Category: Bashan A]]
[[Category: Kinashi, H]]
[[Category: Belousoff MJ]]
[[Category: Rozenberg, H]]
[[Category: Kinashi H]]
[[Category: Shapira, T]]
[[Category: Rozenberg H]]
[[Category: Yonath, A]]
[[Category: Shapira T]]
[[Category: Zimmerman, E]]
[[Category: Yonath A]]
[[Category: Lankacidin]]
[[Category: Zimmerman E]]
[[Category: Lankamycin]]
[[Category: Large ribosomal subunit]]
[[Category: Macrolide]]
[[Category: Ribonucleoprotein]]
[[Category: Ribosomal protein]]
[[Category: Ribosome]]
[[Category: Ribosome-antibiotic complex]]
[[Category: Rna-binding]]
[[Category: Rrna-binding]]
[[Category: Trna-binding]]
Retrieved from "https://proteopedia.org/3pip"