4ab1: Difference between revisions

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==Recombinant Human Carboxylesterase 1 from whole Cabbage Loopers==
==Recombinant Human Carboxylesterase 1 from whole Cabbage Loopers==
<StructureSection load='4ab1' size='340' side='right' caption='[[4ab1]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4ab1' size='340' side='right'caption='[[4ab1]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ab1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AB1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ab1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AB1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mx1|1mx1]], [[1mx5|1mx5]], [[1mx9|1mx9]], [[1ya4|1ya4]], [[1ya8|1ya8]], [[1yah|1yah]], [[1yaj|1yaj]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ab1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ab1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ab1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ab1 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ab1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ab1 OCA], [https://pdbe.org/4ab1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ab1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ab1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ab1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EST1_HUMAN EST1_HUMAN] Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.<ref>PMID:7980644</ref> <ref>PMID:9169443</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4ab1" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Carboxylesterase|Carboxylesterase]]
*[[Carboxylesterase|Carboxylesterase]]
*[[Journal:Acta Cryst F:1|Journal:Acta Cryst F:1]]
*[[Carboxylesterase 3D structures|Carboxylesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cerasoli, D M]]
[[Category: Large Structures]]
[[Category: Greenblatt, H M]]
[[Category: Cerasoli DM]]
[[Category: Otto, T C]]
[[Category: Greenblatt HM]]
[[Category: Sussman, J L]]
[[Category: Otto TC]]
[[Category: Hydrolase]]
[[Category: Sussman JL]]
[[Category: Whole insect expression system]]
Retrieved from "https://proteopedia.org/4ab1"