3ow2: Difference between revisions

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==Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit==
==Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit==
<StructureSection load='3ow2' size='340' side='right' caption='[[3ow2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3ow2' size='340' side='right'caption='[[3ow2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ow2]] is a 29 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OW2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ow2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OW2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EMK:(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ETHYL-3,4,10-TRIHYDROXY-3,5,6,8,10,12,14-HEPTAMETHYL-15-OXO-11-[(3,4,6-TRIDEOXY-3-{[3-(1-{(1S,2R)-1-(FLUOROMETHYL)-2-HYDROXY-2-[4-(METHYLSULFONYL)PHENYL]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)PROPYL](METHYL)AMINO}-BETA-D-XYLO-HEXOPYRANOSYL)OXY]-1-OXA-6-AZACYCLOPENTADECAN-13-YL+2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L-RIBO-HEXOPYRANOSIDE'>EMK</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ow2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ow2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ow2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ow2 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EMK:(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ETHYL-3,4,10-TRIHYDROXY-3,5,6,8,10,12,14-HEPTAMETHYL-15-OXO-11-[(3,4,6-TRIDEOXY-3-{[3-(1-{(1S,2R)-1-(FLUOROMETHYL)-2-HYDROXY-2-[4-(METHYLSULFONYL)PHENYL]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)PROPYL](METHYL)AMINO}-BETA-D-XYLO-HEXOPYRANOSYL)OXY]-1-OXA-6-AZACYCLOPENTADECAN-13-YL+2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L-RIBO-HEXOPYRANOSIDE'>EMK</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ow2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ow2 OCA], [https://pdbe.org/3ow2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ow2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ow2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ow2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL2_HALMA RL2_HALMA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
[[Category: Kanyo, Z F]]
[[Category: Large Structures]]
[[Category: Macrolide binding]]
[[Category: Kanyo ZF]]
[[Category: Protein translation]]
[[Category: Ribosome]]
Retrieved from "https://proteopedia.org/3ow2"