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[[Image:1pkm.jpg|left|200px]]


{{Structure
==THE REFINED THREE-DIMENSIONAL STRUCTURE OF CAT MUSCLE (M1) PYRUVATE KINASE, AT A RESOLUTION OF 2.6 ANGSTROMS==
|PDB= 1pkm |SIZE=350|CAPTION= <scene name='initialview01'>1pkm</scene>, resolution 2.6&Aring;
<StructureSection load='1pkm' size='340' side='right'caption='[[1pkm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1pkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Felis_catus Felis catus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKM FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkm OCA], [https://pdbe.org/1pkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pkm RCSB], [https://www.ebi.ac.uk/pdbsum/1pkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkm ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/KPYM_FELCA KPYM_FELCA] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pkm ConSurf].
<div style="clear:both"></div>


'''THE REFINED THREE-DIMENSIONAL STRUCTURE OF CAT MUSCLE (M1) PYRUVATE KINASE, AT A RESOLUTION OF 2.6 ANGSTROMS'''
==See Also==
 
*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The three-dimensional structure of cat-muscle pyoruvate kinase has been refined at a resolution of 2.6 A. The details of the structure permit interpretation of the original heavy-atom studies and give insight into the importance of conserved residues in pyruvate kinases and the allosteric behaviour of the enzyme. There are a small number of essential residues which determine the relative orientations of domains and the precise nature of intersubunit contacts. Arginine residues are particularly important.
 
==About this Structure==
1PKM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Felis_catus Felis catus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKM OCA].
 
==Reference==
Refined three-dimensional structure of cat-muscle (M1) pyruvate kinase at a resolution of 2.6 A., Allen SC, Muirhead H, Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):499-504. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299671 15299671]
[[Category: Felis catus]]
[[Category: Felis catus]]
[[Category: Pyruvate kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Allen SC]]
[[Category: Allen, S C.]]
[[Category: Muirhead H]]
[[Category: Muirhead, H.]]
[[Category: pyruvate kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:25:36 2008''
Retrieved from "https://proteopedia.org/1pkm"