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==Cholest-4-en-3-one bound structure of CYP142 from Mycobacterium smegmatis==
==Cholest-4-en-3-one bound structure of CYP142 from Mycobacterium smegmatis==
<StructureSection load='2yoo' size='340' side='right' caption='[[2yoo]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
<StructureSection load='2yoo' size='340' side='right'caption='[[2yoo]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yoo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YOO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yoo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K2B:(8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE'>K2B</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bb8|4bb8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K2B:(8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE'>K2B</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yoo RCSB], [http://www.ebi.ac.uk/pdbsum/2yoo PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoo OCA], [https://pdbe.org/2yoo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yoo RCSB], [https://www.ebi.ac.uk/pdbsum/2yoo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CP142_MYCS2 CP142_MYCS2] Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.<ref>PMID:23489718</ref> <ref>PMID:25210044</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2yoo" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycobacterium smegmatis str. mc2 155]]
[[Category: Large Structures]]
[[Category: Frank, D J]]
[[Category: Mycolicibacterium smegmatis MC2 155]]
[[Category: Galan, B]]
[[Category: Frank DJ]]
[[Category: Garcia, J L]]
[[Category: Galan B]]
[[Category: Garcia-Fernandez, E]]
[[Category: Garcia JL]]
[[Category: Kells, P M]]
[[Category: Garcia-Fernandez E]]
[[Category: Montellano, P R.Ortiz de]]
[[Category: Kells PM]]
[[Category: Podust, L M]]
[[Category: Ortiz de Montellano PR]]
[[Category: Cholesterol metabolism]]
[[Category: Podust LM]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2yoo"