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[[Image:1q5f.jpg|left|200px]]


{{Structure
==NMR Structure of Type IVb pilin (PilS) from Salmonella typhi==
|PDB= 1q5f |SIZE=350|CAPTION= <scene name='initialview01'>1q5f</scene>
<StructureSection load='1q5f' size='340' side='right'caption='[[1q5f]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1q5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi Salmonella enterica subsp. enterica serovar Typhi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q5F FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= PilS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=601 Salmonella typhi])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5f OCA], [https://pdbe.org/1q5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q5f RCSB], [https://www.ebi.ac.uk/pdbsum/1q5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q5f ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9ZIU9_SALTI Q9ZIU9_SALTI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/1q5f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q5f ConSurf].
<div style="clear:both"></div>


'''NMR Structure of Type IVb pilin (PilS) from Salmonella typhi'''
==See Also==
 
*[[Pilin 3D structures|Pilin 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The structure of the N-terminal-truncated Type IVb structural pilin (t-PilS) from Salmonella typhi was determined by NMR. Although topologically similar to the recently determined x-ray structure of pilin from Vibrio cholerae toxin-coregulated pilus, the only Type IVb pilin with known structure, t-PilS contains many distinct structural features. The protein contains an extra pair of beta-strands in the N-terminal alphabeta loop that align with the major beta-strands to form a continuous 7-stranded antiparallel beta-sheet. The C-terminal disulfide-bonded region of t-PilS is only half the length of that of toxin-coregulated pilus pilin. A model of S. typhi pilus has been proposed and mutagenesis studies suggested that residues on both the alphabeta loop and the C-terminal disulfide-bonded region of PilS might be involved in binding specificity of the pilus. This model structure reveals an exposed surface between adjacent subunits of PilS that could be a potential binding site for the cystic fibrosis transmembrane conductance regulator.
[[Category: Large Structures]]
 
[[Category: Salmonella enterica subsp. enterica serovar Typhi]]
==About this Structure==
[[Category: Hackett J]]
1Q5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhi Salmonella typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA].
[[Category: Mok YK]]
 
[[Category: Tan YW]]
==Reference==
[[Category: Xu XF]]
NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus., Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK, J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15159389 15159389]
[[Category: Zhang M]]
[[Category: Salmonella typhi]]
[[Category: Single protein]]
[[Category: Hackett, J.]]
[[Category: Mok, Y K.]]
[[Category: Tan, Y W.]]
[[Category: Xu, X F.]]
[[Category: Zhang, M.]]
[[Category: alpha-beta roll]]
[[Category: monomer]]
[[Category: type ivb pilin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:33:14 2008''
Retrieved from "https://proteopedia.org/1q5f"