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==Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant==
==Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant==
<StructureSection load='3l28' size='340' side='right' caption='[[3l28]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3l28' size='340' side='right'caption='[[3l28]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l28]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L28 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l28]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L28 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fke|3fke]], [[3l25|3l25]], [[3l26|3l26]], [[3l27|3l27]], [[3l29|3l29]], [[3l2a|3l2a]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l28 OCA], [https://pdbe.org/3l28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l28 RCSB], [https://www.ebi.ac.uk/pdbsum/3l28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l28 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP35 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186538 Zaire ebolavirus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l28 RCSB], [http://www.ebi.ac.uk/pdbsum/3l28 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3l28" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Zaire ebolavirus]]
[[Category: Ebola virus - Mayinga, Zaire, 1976]]
[[Category: Amarasinghe, G K]]
[[Category: Large Structures]]
[[Category: Basler, C F]]
[[Category: Amarasinghe GK]]
[[Category: Borek, D M]]
[[Category: Basler CF]]
[[Category: Farahbakhsh, M]]
[[Category: Borek DM]]
[[Category: Helgeson, L A]]
[[Category: Farahbakhsh M]]
[[Category: Honzatko, R B]]
[[Category: Helgeson LA]]
[[Category: Leung, D W]]
[[Category: Honzatko RB]]
[[Category: Nix, J C]]
[[Category: Leung DW]]
[[Category: Otwinowski, Z]]
[[Category: Nix JC]]
[[Category: Prins, K C]]
[[Category: Otwinowski Z]]
[[Category: Ramanan, P]]
[[Category: Prins KC]]
[[Category: Tufariello, J M]]
[[Category: Ramanan P]]
[[Category: Host cytoplasm]]
[[Category: Tufariello JM]]
[[Category: Interferon antiviral evasion]]
[[Category: Interferon antiviral system evasion]]
[[Category: Rna binding domain]]
[[Category: Rna binding protein]]
[[Category: Rna replication]]
[[Category: Rna-binding]]
[[Category: Rna-binding protein]]
[[Category: Transcription]]
[[Category: Virion]]
Retrieved from "https://proteopedia.org/3l28"