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==Crystal structure of the cysteine protease inhibitor, EhICP2, from Entamoeba histolytica==
==Crystal structure of the cysteine protease inhibitor, EhICP2, from Entamoeba histolytica==
<StructureSection load='3m88' size='340' side='right' caption='[[3m88]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3m88' size='340' side='right'caption='[[3m88]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3m88]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M88 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3m88]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M88 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m86|3m86]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EHI_040460, ICP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5759 Entamoeba histolytica])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m88 OCA], [https://pdbe.org/3m88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m88 RCSB], [https://www.ebi.ac.uk/pdbsum/3m88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m88 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m88 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m88 RCSB], [http://www.ebi.ac.uk/pdbsum/3m88 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C4M2H5_ENTH1 C4M2H5_ENTH1] Cysteine protease inhibitor (PubMed:16802137, PubMed:16979632, PubMed:21440496, PubMed:32731033, PubMed:20951777). Inhibits cysteine proteases CP1, CP2 and to a lesser extent CP5 (PubMed:16979632).<ref>PMID:16802137</ref> <ref>PMID:16979632</ref> <ref>PMID:20951777</ref> <ref>PMID:21440496</ref> <ref>PMID:32731033</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3m88" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Entamoeba histolytica]]
[[Category: Entamoeba histolytica HM-1:IMSS]]
[[Category: Brieba, L G]]
[[Category: Large Structures]]
[[Category: Casados-Vazquez, L E]]
[[Category: Brieba LG]]
[[Category: Lara-Gonzalez, S]]
[[Category: Casados-Vazquez LE]]
[[Category: Cysteine protease inhibitor]]
[[Category: Lara-Gonzalez S]]
[[Category: Protease]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/3m88"