1qva: Difference between revisions

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[[Image:1qva.jpg|left|200px]]


{{Structure
==YEAST INITIATION FACTOR 4A N-TERMINAL DOMAIN==
|PDB= 1qva |SIZE=350|CAPTION= <scene name='initialview01'>1qva</scene>, resolution 2.50&Aring;
<StructureSection load='1qva' size='340' side='right'caption='[[1qva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[1qva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVA FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qva OCA], [https://pdbe.org/1qva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qva RCSB], [https://www.ebi.ac.uk/pdbsum/1qva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qva ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''YEAST INITIATION FACTOR 4A N-TERMINAL DOMAIN'''
[https://www.uniprot.org/uniprot/IF4A_YEAST IF4A_YEAST]
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The eukaryotic translation initiation factor 4A (elF4A) is a representative of the DEAD-box RNA helicase protein family. We have solved the crystallographic structure of the amino-terminal domain (residues 1-223) of yeast elF4A. The domain is built around a core scaffold, a parallel alpha-beta motif with five beta strands, that is found in other RNA and DNA helicases, as well as in the RecA protein. The amino acid sequence motifs that are conserved within the helicase family are localized to the beta strand--&gt;alpha helix junctions within the core. The core of the amino terminal domain of elF4A is amplified with additional structural elements that differ from those of other helicases. The phosphate binding loop (the Walker A motif) is in an unusual closed conformation. The crystallographic structure reveals specific interactions between amino acid residues of the phosphate binding loop, the DEAD motif, and the SAT motif, whose alteration is known to impair coupling between the ATPase cycle and the RNA unwinding activity of elF4A.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/1qva_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1QVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVA OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qva ConSurf].
Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase., Johnson ER, McKay DB, RNA. 1999 Dec;5(12):1526-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10606264 10606264]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Johnson ER]]
[[Category: Johnson, E R.]]
[[Category: McKay DB]]
[[Category: McKay, D B.]]
[[Category: dead box]]
[[Category: eif4a]]
[[Category: rna helicase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:43:12 2008''

Latest revision as of 08:18, 14 February 2024

YEAST INITIATION FACTOR 4A N-TERMINAL DOMAIN

1qva, resolution 2.50Å

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