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==Structure of COI1-ASK1 in complex with JA-isoleucine and the JAZ1 degron==
==Structure of COI1-ASK1 in complex with JA-isoleucine and the JAZ1 degron==
<StructureSection load='3ogl' size='340' side='right' caption='[[3ogl]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
<StructureSection load='3ogl' size='340' side='right'caption='[[3ogl]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ogl]] is a 23 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OGL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ogl]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OGL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7JA:N-({(1R,2S)-3-OXO-2-[(2Z)-PENT-2-EN-1-YL]CYCLOPENTYL}ACETYL)-L-ISOLEUCINE'>7JA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.18&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ogm|3ogm]], [[3ogk|3ogk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7JA:N-({(1R,2S)-3-OXO-2-[(2Z)-PENT-2-EN-1-YL]CYCLOPENTYL}ACETYL)-L-ISOLEUCINE'>7JA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SKP1A, ASK1, SKP1, UIP1, At1g75950, T4O12.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana]), COI1, FBL2, At2g39940, T28M21.10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ogl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ogl OCA], [https://pdbe.org/3ogl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ogl RCSB], [https://www.ebi.ac.uk/pdbsum/3ogl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ogl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ogl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ogl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ogl RCSB], [http://www.ebi.ac.uk/pdbsum/3ogl PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/COI1_ARATH COI1_ARATH] Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles in regulating response to jasmonate, and their interactions with the COP9 signalosome (CSN) appear to be important for their activity. Interacts with TIFY10A and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. Involved in the regulation of plant gene expression during plant-pathogen interactions with Pseudomonas syringae and Alternaria brassicicola.<ref>PMID:9582125</ref> <ref>PMID:12244256</ref> <ref>PMID:10810145</ref> <ref>PMID:12172836</ref> <ref>PMID:12172031</ref> <ref>PMID:12445118</ref> <ref>PMID:12724535</ref> <ref>PMID:12805591</ref> <ref>PMID:14756769</ref>  
Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JAZ proteins. Despite its importance, the mechanism of jasmonate perception remains unclear. Here we present structural and pharmacological data to show that the true Arabidopsis jasmonate receptor is a complex of both COI1 and JAZ. COI1 contains an open pocket that recognizes the bioactive hormone (3R,7S)-jasmonoyl-l-isoleucine (JA-Ile) with high specificity. High-affinity hormone binding requires a bipartite JAZ degron sequence consisting of a conserved alpha-helix for COI1 docking and a loop region to trap the hormone in its binding pocket. In addition, we identify a third critical component of the jasmonate co-receptor complex, inositol pentakisphosphate, which interacts with both COI1 and JAZ adjacent to the ligand. Our results unravel the mechanism of jasmonate perception and highlight the ability of F-box proteins to evolve as multi-component signalling hubs.
 
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.,Sheard LB, Tan X, Mao H, Withers J, Ben-Nissan G, Hinds TR, Kobayashi Y, Hsu FF, Sharon M, Browse J, He SY, Rizo J, Howe GA, Zheng N Nature. 2010 Nov 18;468(7322):400-5. Epub 2010 Oct 6. PMID:20927106<ref>PMID:20927106</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Ben-Nissan, G]]
[[Category: Large Structures]]
[[Category: Browse, J]]
[[Category: Ben-Nissan G]]
[[Category: He, S Y]]
[[Category: Browse J]]
[[Category: Hinds, T R]]
[[Category: He SY]]
[[Category: Howe, G A]]
[[Category: Hinds TR]]
[[Category: Hsu, F]]
[[Category: Howe GA]]
[[Category: Mao, H]]
[[Category: Hsu F]]
[[Category: Rizo, J]]
[[Category: Mao H]]
[[Category: Sharon, M]]
[[Category: Rizo J]]
[[Category: Sheard, L B]]
[[Category: Sharon M]]
[[Category: Tan, X]]
[[Category: Sheard LB]]
[[Category: Withers, J]]
[[Category: Tan X]]
[[Category: Zheng, N]]
[[Category: Withers J]]
[[Category: Leucine-rich repeat]]
[[Category: Zheng N]]
[[Category: Protein binding]]
[[Category: Scf]]
[[Category: Ubiquitin ligase]]

Latest revision as of 10:34, 21 February 2024

Structure of COI1-ASK1 in complex with JA-isoleucine and the JAZ1 degron

3ogl, resolution 3.18Å

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