3q1c: Difference between revisions

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==Structure of EspG Protein==
==Structure of EspG Protein==
<StructureSection load='3q1c' size='340' side='right' caption='[[3q1c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3q1c' size='340' side='right'caption='[[3q1c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q1c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127:h6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1C FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O127:H6_str._E2348/69 Escherichia coli O127:H6 str. E2348/69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q1C FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2348C_3970, E2348_C_3970, espG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=168807 Escherichia coli O127:H6])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.596&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1c RCSB], [http://www.ebi.ac.uk/pdbsum/3q1c PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1c OCA], [https://pdbe.org/3q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q1c RCSB], [https://www.ebi.ac.uk/pdbsum/3q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1c ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/B7UMC8_ECO27 B7UMC8_ECO27]
Bacterial pathogens secrete effectors into their hosts that subvert host defenses and redirect host processes. EspG is a type three secretion effector with a disputed function that is found in enteropathogenic Escherichia coli. Here we show that EspG is structurally similar to VirA, a Shigella virulence factor; EspG has a large, conserved pocket on its surface; EspG binds directly to the amino-terminal inhibitory domain of human p21-activated kinase (PAK); and mutations to conserved residues in the surface pocket disrupt the interaction with PAK.
 
Structural and Functional Studies Indicate That the EPEC Effector, EspG, Directly Binds p21-Activated Kinase.,Germane KL, Spiller BW Biochemistry. 2011 Feb 15;50(6):917-9. Epub 2011 Jan 24. PMID:21235237<ref>PMID:21235237</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli o127:h6]]
[[Category: Escherichia coli O127:H6 str. E2348/69]]
[[Category: Germane, K L]]
[[Category: Large Structures]]
[[Category: Spiller, B W]]
[[Category: Germane KL]]
[[Category: P21 activated kinase]]
[[Category: Spiller BW]]
[[Category: Pak recruitment and activation]]
[[Category: Signaling protein]]
[[Category: Vira fold]]
[[Category: Virulence factor]]
Retrieved from "https://proteopedia.org/3q1c"