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==Crystal structure of the human squalene synthase in complex with zaragozic acid A==
==Crystal structure of the human squalene synthase in complex with zaragozic acid A==
<StructureSection load='3vjc' size='340' side='right' caption='[[3vjc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='3vjc' size='340' side='right'caption='[[3vjc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vjc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VJC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vjc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VJC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZGA:ZARAGOZIC+ACID+A'>ZGA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vj8|3vj8]], [[3vj9|3vj9]], [[3vja|3vja]], [[3vjb|3vjb]], [[3vjd|3vjd]], [[3vje|3vje]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZGA:ZARAGOZIC+ACID+A'>ZGA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vjc OCA], [https://pdbe.org/3vjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vjc RCSB], [https://www.ebi.ac.uk/pdbsum/3vjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vjc ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vjc RCSB], [http://www.ebi.ac.uk/pdbsum/3vjc PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3vjc" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Squalene synthase]]
[[Category: Large Structures]]
[[Category: Chang, W J]]
[[Category: Chang WJ]]
[[Category: Jeng, W Y]]
[[Category: Jeng WY]]
[[Category: Ko, T P]]
[[Category: Ko TP]]
[[Category: Liu, C I]]
[[Category: Liu CI]]
[[Category: Wang, A H.J]]
[[Category: Wang AHJ]]
[[Category: Cholesterol biosynthesis]]
[[Category: Farnesyl-diphosphate farnesyltransferase]]
[[Category: Head-to-head synthase]]
[[Category: Oxidoreductase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/3vjc"