|
|
| (11 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| [[Image:1rid.gif|left|200px]]
| | <span style='background-color: yellow;'>For additional information see '''2009, December:''' at [[Retractions and Fraud]].</span></br>REMOVED: The PDB entry 1rid was removed. |
| | |
| {{Structure
| |
| |PDB= 1rid |SIZE=350|CAPTION= <scene name='initialview01'>1rid</scene>, resolution 2.1Å
| |
| |SITE=
| |
| |LIGAND=
| |
| |ACTIVITY=
| |
| |GENE= C3L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])
| |
| }}
| |
| | |
| '''Vaccinia Complement Protein in Complex with Heparin''' | |
| | |
| | |
| ==Overview==
| |
| Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that assists vaccinia in host interactions. Interaction with cell-surface polyanions like heparin is centrally important in the functioning of fluid-phase complement regulators and is the basis of host-target discrimination by the alternative pathway. We report the structure of VCP in complex with a heparin decasaccharide, which reveals changes in VCP that might be pertinent to complement regulation. Properties that VCP shares with fluid-phase complement regulators suggest that such conformational changes may be of relevance in the functioning of other complement regulators. Additionally, comparison of VCP-heparin interactions with potentially similar interactions in factor H might enable understanding of the structural basis of familial hemolytic uremic syndrome, attributed to mutational disruption of heparin and C3b binding by factor H.
| |
| | |
| ==About this Structure==
| |
| 1RID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RID OCA].
| |
| | |
| ==Reference==
| |
| Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation., Ganesh VK, Smith SA, Kotwal GJ, Murthy KH, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8924-9. Epub 2004 Jun 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15178763 15178763]
| |
| [[Category: Single protein]]
| |
| [[Category: Vaccinia virus]]
| |
| [[Category: Ganesh, V K.]]
| |
| [[Category: Kotwal, G J.]]
| |
| [[Category: Murthy, K H.M.]]
| |
| [[Category: Smith, S A.]]
| |
| [[Category: complement]]
| |
| [[Category: regulation]]
| |
| [[Category: scr]]
| |
| | |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:52:01 2008''
| |
For additional information see 2009, December: at Retractions and Fraud.
REMOVED: The PDB entry 1rid was removed.
