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==Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with kainate==
==Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with kainate==
<StructureSection load='4bdo' size='340' side='right' caption='[[4bdo]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='4bdo' size='340' side='right'caption='[[4bdo]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bdo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BDO FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bdo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BDO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s50|1s50]], [[1s7y|1s7y]], [[1s9t|1s9t]], [[1sd3|1sd3]], [[1tt1|1tt1]], [[1yae|1yae]], [[2i0b|2i0b]], [[2i0c|2i0c]], [[2xxr|2xxr]], [[2xxt|2xxt]], [[2xxu|2xxu]], [[2xxv|2xxv]], [[2xxw|2xxw]], [[2xxx|2xxx]], [[2xxy|2xxy]], [[4bdl|4bdl]], [[4bdm|4bdm]], [[4bdn|4bdn]], [[4bdq|4bdq]], [[4bdr|4bdr]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bdo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bdo RCSB], [http://www.ebi.ac.uk/pdbsum/4bdo PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bdo OCA], [https://pdbe.org/4bdo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bdo RCSB], [https://www.ebi.ac.uk/pdbsum/4bdo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bdo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4bdo" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Green, T]]
[[Category: Green T]]
[[Category: Mayans, O]]
[[Category: Mayans O]]
[[Category: Nayeem, N]]
[[Category: Nayeem N]]
[[Category: Ionotropic glutamate receptor]]
[[Category: Kainate receptor]]
[[Category: Metal transport]]
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