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==Cystal structure of locked-trimer of human MIF==
==Cystal structure of locked-trimer of human MIF==
<StructureSection load='4gum' size='340' side='right' caption='[[4gum]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='4gum' size='340' side='right'caption='[[4gum]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gum]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GUM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gum]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 Macaca mulatta])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gum RCSB], [http://www.ebi.ac.uk/pdbsum/4gum PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gum OCA], [https://pdbe.org/4gum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gum RCSB], [https://www.ebi.ac.uk/pdbsum/4gum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gum ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MIF_MACMU MIF_MACMU] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4gum" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Macrophage inhibitory factor|Macrophage inhibitory factor]]
*[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Macaca mulatta]]
[[Category: Homo sapiens]]
[[Category: Fan, C]]
[[Category: Large Structures]]
[[Category: Lolis, E]]
[[Category: Fan C]]
[[Category: Alpha/beta mixture]]
[[Category: Lolis E]]
[[Category: Cytokine and isomerase]]
[[Category: Isomerase]]
Retrieved from "https://proteopedia.org/4gum"