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==Crystal Structure of full length transcription repressor LsrR from E. coli.==
==Crystal Structure of full length transcription repressor LsrR from E. coli.==
<StructureSection load='4go1' size='340' side='right' caption='[[4go1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4go1' size='340' side='right'caption='[[4go1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4go1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GO1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4go1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GO1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1512, JW1505, lsrR, ydeW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4go1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4go1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4go1 RCSB], [http://www.ebi.ac.uk/pdbsum/4go1 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4go1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4go1 OCA], [https://pdbe.org/4go1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4go1 RCSB], [https://www.ebi.ac.uk/pdbsum/4go1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4go1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LSRR_ECOLI LSRR_ECOLI] Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.<ref>PMID:15601708</ref> <ref>PMID:15743955</ref> <ref>PMID:17557827</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4go1" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli K-12]]
[[Category: Liu, X]]
[[Category: Large Structures]]
[[Category: Tao, Y]]
[[Category: Liu X]]
[[Category: Wu, M]]
[[Category: Tao Y]]
[[Category: Zang, J]]
[[Category: Wu M]]
[[Category: Hth motif]]
[[Category: Zang J]]
[[Category: P-ai-2]]
[[Category: Sorc/deor family]]
[[Category: Transcription]]
[[Category: Transcription repressor]]
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