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==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor anthrapyrazolone SP600125==
==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor anthrapyrazolone SP600125==
<StructureSection load='4feu' size='340' side='right' caption='[[4feu]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
<StructureSection load='4feu' size='340' side='right'caption='[[4feu]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4feu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FEU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4feu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=537:2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE'>537</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=537:2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE'>537</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ej7|4ej7]], [[4fev|4fev]], [[4few|4few]], [[4fex|4fex]], [[4gkh|4gkh]], [[4gki|4gki]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4feu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feu OCA], [https://pdbe.org/4feu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4feu RCSB], [https://www.ebi.ac.uk/pdbsum/4feu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4feu ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABAYE3578, APHA1-IAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=509173 Acinetobacter baumannii AYE])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kanamycin_kinase Kanamycin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.95 2.7.1.95] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4feu RCSB], [http://www.ebi.ac.uk/pdbsum/4feu PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4feu" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Phosphotransferase|Phosphotransferase]]
*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acinetobacter baumannii aye]]
[[Category: Acinetobacter baumannii AYE]]
[[Category: Kanamycin kinase]]
[[Category: Large Structures]]
[[Category: Anderson, W F]]
[[Category: Anderson WF]]
[[Category: Structural genomic]]
[[Category: Di Leo R]]
[[Category: Egorova, O]]
[[Category: Egorova O]]
[[Category: Evdokimova, E]]
[[Category: Evdokimova E]]
[[Category: Leo, R Di]]
[[Category: Minasov G]]
[[Category: Minasov, G]]
[[Category: Savchenko A]]
[[Category: Savchenko, A]]
[[Category: Shakya T]]
[[Category: Shakya, T]]
[[Category: Spanogiannopoulos P]]
[[Category: Spanogiannopoulos, P]]
[[Category: Stogios PJ]]
[[Category: Stogios, P J]]
[[Category: Wawrzak Z]]
[[Category: Wawrzak, Z]]
[[Category: Wright GD]]
[[Category: Wright, G D]]
[[Category: Alpha/beta protein]]
[[Category: Aminoglycoside phosphotransferase]]
[[Category: Aminoglycoside]]
[[Category: Anthrapyrazolone]]
[[Category: Antibiotic resistance]]
[[Category: Csgid]]
[[Category: Eukaryotic protein kinase-like fold]]
[[Category: Gtp]]
[[Category: Intracellular]]
[[Category: Kanamycin]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Phosphotransferase]]
[[Category: Protein kinase inhibitor]]
[[Category: Sp600125]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4feu"