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==Crystal structure of the Mtb enoyl CoA isomerase (Rv0632c) in complex with hydroxybutyrl CoA==
==Crystal structure of the Mtb enoyl CoA isomerase (Rv0632c) in complex with hydroxybutyrl CoA==
<StructureSection load='4fnb' size='340' side='right' caption='[[4fnb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4fnb' size='340' side='right'caption='[[4fnb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FNB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FNB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HC:3-HYDROXYBUTANOYL-COENZYME+A'>3HC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fn7|4fn7]], [[4fn8|4fn8]], [[4fnd|4fnd]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3HC:3-HYDROXYBUTANOYL-COENZYME+A'>3HC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">echA3, MT0660, Rv0632c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fnb OCA], [https://pdbe.org/4fnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fnb RCSB], [https://www.ebi.ac.uk/pdbsum/4fnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fnb ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fnb RCSB], [http://www.ebi.ac.uk/pdbsum/4fnb PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P96907_MYCTX P96907_MYCTX]


==See Also==
==See Also==
*[[Enoyl-CoA hydratase|Enoyl-CoA hydratase]]
*[[Enoyl-CoA hydratase 3D structures|Enoyl-CoA hydratase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Enoyl-CoA hydratase]]
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Bruning, J B]]
[[Category: Bruning JB]]
[[Category: Dang, N]]
[[Category: Dang N]]
[[Category: Gao, N]]
[[Category: Gao N]]
[[Category: Hernandez, E D]]
[[Category: Hernandez ED]]
[[Category: Hung, L W]]
[[Category: Hung LW]]
[[Category: Li, H]]
[[Category: Li H]]
[[Category: Sacchettini, J C]]
[[Category: Sacchettini JC]]
[[Category: Structural genomic]]
[[Category: Crotonase superfamily]]
[[Category: Isomerase]]
[[Category: Tbsgc]]

Latest revision as of 15:29, 14 March 2024

Crystal structure of the Mtb enoyl CoA isomerase (Rv0632c) in complex with hydroxybutyrl CoA

4fnb, resolution 1.80Å

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