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==Crystal structure of thymidylate synthase from Corynebacterium glutamicum in complex with dUMP==
==Crystal structure of thymidylate synthase from Corynebacterium glutamicum in complex with dUMP==
<StructureSection load='4h0u' size='340' side='right' caption='[[4h0u]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='4h0u' size='340' side='right'caption='[[4h0u]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h0u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum_atcc_13032 Corynebacterium glutamicum atcc 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H0U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h0u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum_ATCC_13032 Corynebacterium glutamicum ATCC 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H0U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cg0966, Cgl0844, thyA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196627 Corynebacterium glutamicum ATCC 13032])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h0u OCA], [https://pdbe.org/4h0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h0u RCSB], [https://www.ebi.ac.uk/pdbsum/4h0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h0u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h0u RCSB], [http://www.ebi.ac.uk/pdbsum/4h0u PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_CORGL TYSY_CORGL] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).


==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Corynebacterium glutamicum atcc 13032]]
[[Category: Corynebacterium glutamicum ATCC 13032]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Chang, C M]]
[[Category: Chang CM]]
[[Category: Wang, W C]]
[[Category: Wang WC]]
[[Category: Dump]]
[[Category: Nucleotide]]
[[Category: Transferase]]

Latest revision as of 14:03, 8 November 2023

Crystal structure of thymidylate synthase from Corynebacterium glutamicum in complex with dUMP

4h0u, resolution 2.75Å

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