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==Crystal Structure of the TrkA Gating ring bound to ATP-gamma-S==
==Crystal Structure of the TrkA Gating ring bound to ATP-gamma-S==
<StructureSection load='4j9v' size='340' side='right' caption='[[4j9v]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
<StructureSection load='4j9v' size='340' side='right'caption='[[4j9v]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4j9v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_rimd_2210633 Vibrio parahaemolyticus rimd 2210633]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J9V FirstGlance]. <br>
<table><tr><td colspan='2'>[[4j9v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_RIMD_2210633 Vibrio parahaemolyticus RIMD 2210633]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J9V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.051&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j9u|4j9u]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP3045 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223926 Vibrio parahaemolyticus RIMD 2210633])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9v OCA], [https://pdbe.org/4j9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j9v RCSB], [https://www.ebi.ac.uk/pdbsum/4j9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j9v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j9v RCSB], [http://www.ebi.ac.uk/pdbsum/4j9v PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q87KD2_VIBPA Q87KD2_VIBPA]
TrkH belongs to a superfamily of K(+) transport proteins required for growth of bacteria in low external K(+) concentrations. The crystal structure of TrkH from Vibrio parahaemolyticus showed that TrkH resembles a K(+) channel and may have a gating mechanism substantially different from K(+) channels. TrkH assembles with TrkA, a cytosolic protein comprising two RCK (regulate the conductance of K(+)) domains, which are found in certain K(+) channels and control their gating. However, fundamental questions on whether TrkH is an ion channel and how it is regulated by TrkA remain unresolved. Here we show single-channel activity of TrkH that is upregulated by ATP via TrkA. We report two structures of the tetrameric TrkA ring, one in complex with TrkH and one in isolation, in which the ring assumes two markedly different conformations. These results suggest a mechanism for how ATP increases TrkH activity by inducing conformational changes in TrkA.
 
Gating of the TrkH ion channel by its associated RCK protein TrkA.,Cao Y, Pan Y, Huang H, Jin X, Levin EJ, Kloss B, Zhou M Nature. 2013 Apr 18;496(7445):317-22. doi: 10.1038/nature12056. PMID:23598339<ref>PMID:23598339</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[Tyrosine kinase receptor 3D structures|Tyrosine kinase receptor 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibrio parahaemolyticus rimd 2210633]]
[[Category: Large Structures]]
[[Category: Cao, Y]]
[[Category: Vibrio parahaemolyticus RIMD 2210633]]
[[Category: Huang, H]]
[[Category: Cao Y]]
[[Category: Jin, X]]
[[Category: Huang H]]
[[Category: Levin, E J]]
[[Category: Jin X]]
[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure]]
[[Category: Levin EJ]]
[[Category: Zhou, M]]
[[Category: Zhou M]]
[[Category: New york consortium on membrane protein structure]]
[[Category: Nucleotide binding]]
[[Category: Nycomp]]
[[Category: Potassium transport]]
[[Category: Psi-biology]]
[[Category: Rck domain]]
[[Category: Structural genomic]]
[[Category: Transport protein]]

Latest revision as of 12:02, 1 March 2024

Crystal Structure of the TrkA Gating ring bound to ATP-gamma-S

4j9v, resolution 3.05Å

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