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[[Image:1sdb.jpg|left|200px]]


{{Structure
==PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN==
|PDB= 1sdb |SIZE=350|CAPTION= <scene name='initialview01'>1sdb</scene>, resolution 1.65&Aring;
<StructureSection load='1sdb' size='340' side='right'caption='[[1sdb]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1sdb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SDB FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sdb OCA], [https://pdbe.org/1sdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sdb RCSB], [https://www.ebi.ac.uk/pdbsum/1sdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sdb ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.


'''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''
Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution.,Diao JS, Wan ZL, Chang WR, Liang DC Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880<ref>PMID:15299880</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1sdb" style="background-color:#fffaf0;"></div>


==Overview==
==See Also==
Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.
*[[Insulin 3D Structures|Insulin 3D Structures]]
 
== References ==
==About this Structure==
<references/>
1SDB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA].
__TOC__
 
</StructureSection>
==Reference==
[[Category: Large Structures]]
Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution., Diao JS, Wan ZL, Chang WR, Liang DC, Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299880 15299880]
[[Category: Protein complex]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Diao, J S.]]
[[Category: Diao J-S]]
[[Category: Liang, D C.]]
[[Category: Liang D-C]]
[[Category: hormone]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:03:33 2008''

Latest revision as of 21:35, 28 June 2023

PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN

1sdb, resolution 1.65Å

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