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==Crystal structure of Smu.1393c from cariogenic pathogen Streptococcus mutans==
==Crystal structure of Smu.1393c from cariogenic pathogen Streptococcus mutans==
<StructureSection load='4l9a' size='340' side='right' caption='[[4l9a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4l9a' size='340' side='right'caption='[[4l9a]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l80 3l80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L9A FirstGlance]. <br>
<table><tr><td colspan='2'>This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l80 3l80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9a OCA], [https://pdbe.org/4l9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9a RCSB], [https://www.ebi.ac.uk/pdbsum/4l9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9a ProSAT]</span></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMU_1393c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210007 Streptococcus mutans UA159])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l9a RCSB], [http://www.ebi.ac.uk/pdbsum/4l9a PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The protein Smu.1393c from Streptococcus mutans is annotated as a putative alpha/beta hydrolase, but it has low sequence identity to the structure-known alpha/beta hydrolases. Here we present the crystal structure of Smu.1393c at 2.0 A resolution. Smu.1393c has a fully open alkaline substrate pocket, whose conformation is unique among other similar hydrolase structures. Three residues, Ser101, His251, and Glu125, were identified as the active center of Smu.1393c. By screening a series of artificial hydrolase substrates, we demonstrated Smu.1393c had low carboxylesterase activity towards short-chain carboxyl esters, which provided a clue for exploring the in vivo function of Smu.1393c. Proteins 2013; (c) 2013 Wiley Periodicals, Inc.
Structural and functional characterization of a novel alpha/beta hydrolase from cariogenic pathogen Streptococcus mutans.,Wang Z, Li L, Su XD Proteins. 2013 Sep 30. doi: 10.1002/prot.24418. PMID:24115105<ref>PMID:24115105</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptococcus mutans ua159]]
[[Category: Large Structures]]
[[Category: Li, L]]
[[Category: Li L]]
[[Category: Su, X D]]
[[Category: Su X-D]]
[[Category: Wang, Z]]
[[Category: Wang Z]]
[[Category: Alpha/beta hydrolase]]
[[Category: Carboxylesterase]]
[[Category: Hydrolase]]
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